School of Medicine
Harrington Building, HA210
+44 (0) 1772 89 6315
Subject Areas: Biosciences
Dr O’Connor teaches immunology and haematology in the School of Medicine. Her interests are focused on the innate immune system and the Natural Killer (NK) cell subset. Much of her research examines how genetic variation between individuals impacts immune function, and how this may ultimately alter disease outcomes.
While studying for a degree in Biochemistry in Trinity College Dublin Dr O’Connor developed an avid interest in the human immune system and stayed on to do a PhD in Immunology within the School of
Biochemistry and Immunology. After completion of her PhD she spend several years as a postdoctoral fellow at the National Cancer Institute within the NIH in the US before moving as a research fellow to the Department of Microbiology and Immunology at the University of Melbourne.
Throughout her research career, she has worked on various aspects of the human immune system including research on human immunodeficiency (both genetic and acquired), and in understanding how differences between individuals impacts their immune function and ultimately their health.
De Ravin, S. S., Wu, X., Moir, S., Anaya-O'Brien, S., Kwatemaa, N., Littel, P., . . . Kardava, L. (2016). Lentiviral hematopoietic stem cell gene therapy for X-linked severe combined immunodeficiency. Sci Transl Med, 8(335), 335ra357. doi:10.1126/scitranslmed.aad8856
O'Connor, G. M., Vivian, J. P., Gostick, E., Pymm, P., Lafont, B. A., Price, D. A., . . . McVicar, D. W. (2015). Peptide-Dependent Recognition of HLA-B*57:01 by KIR3DS1. J Virol, 89(10), 5213-5221. doi:10.1128/JVI.03586-14
O'Connor, G. M., Vivian, J. P., Widjaja, J. M., Bridgeman, J. S., Gostick, E., Lafont, B. A., . . . McVicar, D. W. (2014). Mutational and structural analysis of KIR3DL1 reveals a lineage-defining allotypic dimorphism that impacts both HLA and peptide sensitivity. J Immunol, 192(6), 2875-2884. doi:10.4049/jimmunol.1303142
Pymm, P., Illing, P. T., Ramarathinam, S. H., O'Connor, G. M., Hughes, V. A., Hitchen, C., . . . Vivian, J. P. (2017). MHC-I peptides get out of the groove and enable a novel mechanism of HIV-1 escape. Nat Struct Mol Biol, 24(4), 387-394. doi:10.1038/nsmb.3381