Dr. Lorenzo More

Senior Lecturer in Neuroscience

School of Pharmacy and Biomedical Sciences

Maudland Building, MB139

+44 (0) 1772 89 5847

LMore@uclan.ac.uk

Subject Areas: Pharmacy and Pharmacology, Allied Health, Biosciences, Psychology

I work in the field of behavioural genetics and molecular cognition. My research final aim is to understand the cellular and molecular mechanisms underlying learning and memory and thus how the brain stores, retrieves and modifies information.

I exploit environmental enrichment (EE), which is known to provide the mammal brain with a "cognitive reserve", in preclinical models in order to shed light on the complex molecular machinery involved in environment adaptation and enhanced cognition.

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Full Profile

Lorenzo More undertook a PhD in Neuroscience at the School of Medicine in Padova in 2005 where he studied the effect of urinary pheromones on ovulation and the role of the olfactory systems.

He then worked in Germany, Italy and the UK on preclinical models of Alzheimer’s, Schizophrenia and Parkinson’s disease and since 2011 on the genetic basis of X-linked Intellectual Disabilities and the molecular bases of environmental adaptation.

A major development of his recent work on Neuro Developmental Disorders (NDDs), EE and nootropics concerns the identification of epigenetic markers of psychopathic traits.

Qualifications
  • Fellow of the Higher Education Academy
    • The University of Warwick (UK) 2017
  • Doctor of Research (PhD) in Neuroscience
    • The University of Padova (Italy) 2005
  • 5-year Laurea (MSc) in Biological Psychology
    • The University of Padova, 2001

Publications

Morè L*, Lauterborn J*, Papaleo F, Brambilla R (2019). Enhancing cognition through pharmacological and environmental interventions: Examples from preclinical models of neurodevelopmental disorders. Neuroscience and Biobehavioral Reviews in press.

Daumas S*, Hunter CJ*, Mistry RB*, Morè L*, Privitera L*, Cooper DD, Reyskens KM, Flynn HT, Morris RGM, Arthur JSC, Frenguelli BG (2017). The kinase function of MSK1 regulates BDNF signaling to CREB and basal synaptic transmission, but is not required for hippocampal long-term potentiation or spatial memory. eNeuro: 4(1): ENEURO.0212-16.2017

Morè L, Künnecke B, Yekhlef L, Bruns A, Bianchi V, Taverna S, Marte A, Fedele E, Gatti S, D'Adamo P (2017) Altered Fronto-Striatal Function in the Gdi1-null mouse model of X-linked Intellectual Disability. Neuroscience 344: 346-359

Pennucci R, Talpo F, Astro V, Montinaro V, Morè L, Cursi M, Castoldi V, Chiaretti S, Bianchi V, Marenna S, Cambiaghi M, Leocani L, Biella G, D’Adamo P, de Curtis I (2016) Rac1 and Rac3 GTPases promote the maturation of hippocampal GABAergic interneurons and influence the development of distinct neuronal networks. Cerebral Cortex 26: 873-890

Research

Molecular Cognition

Projects

  • Biomarkers of antisocial behaviours
  • Environmental and pharmacological strategies to enhance cognition
  • The role of Ras-ERK pathway in major depression

Conferences

Recently Invited speaker

  • Hiroshima (Japan), June 2017 International Behavioral Neuroscience Society (IBNS) 26th Annual Meeting - Oral presentation and symposium co-chair: Environmental and pharmacological strategies to enhance cognition
  • Perugia (Italy), September 2019 Societa Italiana Neuro Scienze (SINS) 18th Congress - Oral presentation: Signalling Pathways in Intellectual Disability and Autism Spectrum Disorder: Cellular Mechanisms, Diagnostic Tools and Therapeutic Approaches

Membership of professional and learned bodies

 

 

Publications continued

Oettinghaus B, Schulz JM, Restelli LM, Licci M, Savoia C, Schmidt A, Schmitt K, Grimm A, Morè L, Hench J, Tolnay M, Eckert A, D`Adamo P, Franken P, Ishihara N, Mihara K, Bischofberger J, Scorrano L, Frank S (2016) Synaptic dysfunction, memory deficits and hippocampal atrophy due to ablation of mitochondrial fission in adult forebrain neurons. Cell Death and Differentiation 23: 18-28

D’Adamo P, Masetti M, Bianchi V, Morè L, Mignogna ML, Giannandrea M, Gatti S (2014 available online) RAB GTPases and RAB-interacting proteins and their role in the control of cognitive functions. Neuroscience & Biobehavioral Reviews 46: 302-314

Morè L, Jensen G (2014) Acquisition of conditioned responding in a multiple schedule depends on the reinforcement’s temporal contingency with each stimulus. Learning & Memory 21: 258-262

Schlumberger C, Pietraszek M, Gravius A, Klein K-U, Greco S, Morè L, Danysz W (2009) Comparison of positive allosteric modulator of mGlu5 receptor ADX47273 and mGluR2/3 agonist LY354740 in tests for antipsychotic-like activity. European Journal of Pharmacology, Behavioural Pharmacology section, 623: 73-83

Schlumberger C, Schaefer D, Barberi C, Morè L, Nagel J, Pietraszek M, Schmidt WJ, Danysz W (2009) Effects of a metabotropic glutamate receptor group II agonist LY354740 in animal models of positive schizophrenia symptoms and cognition. Behavioural Pharmacology, 20: 56-66

Morè L (2008) Intra-Female Aggression in the Mouse (Mus musculus domesticus) is linked to the Estrous Cycle Regularity but not to Ovulation. Aggressive Behavior, 34: 46-50

Morè L, Gravius A, Nagel J, Valastro B, Greco S, Danysz W (2008) Therapeutically relevant plasma concentrations of memantine produce significant NMDA receptor occupation and do not impair learning in rats. Behavioural Pharmacology, 19: 724-734

Gravius A, Dekundy A, Nagel J, Morè L, Pietraszek M, Danysz W (2008) Investigation on tolerance development to subchronic blockade of mGluR5 in models of learning, anxiety, and levodopa-induced dyskinesia in rats. Journal of Neural Transmission, 115: 1609-1619

Morè L*, Gravius A*, Pietraszek M, Belozertseva I, Malyshkin A, Shekunova E, Barberi C, Schaefer D, Schmidt WJ, Danysz W (2007) Comparison of the mGluR1 antagonist A-841720 in rat models of pain and cognition. Behavioural Pharmacology, 18: 273-281

Morè L (2006) Mouse Major Urinary Proteins Trigger Ovulation via the Vomeronasal Organ. Chemical Senses, 31: 393-401

Teaching Activities and Responsibilities

Module leader: BL3220 Advanced Systems Pharmacology

System lead: PJ3300 Systems-Based Patient Care (CNS) | PJ2300 Systems-Based Patient Care (CNS)

Module tutor: BL3299 Research Project | BL4020 Current Trends in Neuroscience (MRes)

Lecturer: BL4014 Research Project (MRes) | BL2215 Biostatistics | PJ1300 Journey of a Medicine | PJ1301 Health and Disease