School of Pharmacy and Biomedical Sciences
Maudland Building, MB139
+44 (0) 1772 89 5847
Subject Areas: Pharmacy and Pharmacology, Allied Health, Biosciences, Psychology
I work in the field of behavioural genetics and molecular cognition. My research final aim is to understand the cellular and molecular mechanisms underlying learning and memory and thus how the brain stores, retrieves and modifies information.
I exploit environmental enrichment (EE), which is known to provide the mammal brain with a "cognitive reserve", in preclinical models in order to shed light on the complex molecular machinery involved in environment adaptation and enhanced cognition.
Lorenzo More undertook a PhD in Neuroscience at the School of Medicine in Padova in 2005 where he studied the effect of urinary pheromones on ovulation and the role of the olfactory systems.
He then worked in Germany, Italy and the UK on preclinical models of Alzheimer’s, Schizophrenia and Parkinson’s disease and since 2011 on the genetic basis of X-linked Intellectual Disabilities and the molecular bases of environmental adaptation.
A major development of his recent work on Neuro Developmental Disorders (NDDs), EE and nootropics concerns the identification of a CNS proteomic signature of antisocial traits.
Shaw A, Arnold LD, Privitera L, Whitfield PD, Doherty MK, Morè L (2020). A proteomic signature for CNS adaptations to the valence of environmental stimulation. Behavioural Brain Research 383: 112515
Morè L*, Lauterborn J*, Papaleo F, Brambilla R (2020). Enhancing cognition through pharmacological and environmental interventions: Examples from preclinical models of neurodevelopmental disorders. Neuroscience and Biobehavioral Reviews. 110: 28-45
Daumas S*, Hunter CJ*, Mistry RB*, Morè L*, Privitera L*, Cooper DD, Reyskens KM, Flynn HT, Morris RGM, Arthur JSC, Frenguelli BG (2017). The kinase function of MSK1 regulates BDNF signaling to CREB and basal synaptic transmission, but is not required for hippocampal long-term potentiation or spatial memory. eNeuro 4(1): ENEURO.0212-16.2017
Morè L, Künnecke B, Yekhlef L, Bruns A, Bianchi V, Taverna S, Marte A, Fedele E, Gatti S, D'Adamo P (2017) Altered Fronto-Striatal Function in the Gdi1-null mouse model of X-linked Intellectual Disability. Neuroscience 344: 346-359
Pennucci R, Talpo F, Astro V, Montinaro V, Morè L, Cursi M, Castoldi V, Chiaretti S, Bianchi V, Marenna S, Cambiaghi M, Leocani L, Biella G, D’Adamo P, de Curtis I (2016) Rac1 and Rac3 GTPases promote the maturation of hippocampal GABAergic interneurons and influence the development of distinct neuronal networks. Cerebral Cortex 26: 873-890
Oettinghaus B, Schulz JM, Restelli LM, Licci M, Savoia C, Schmidt A, Schmitt K, Grimm A, Morè L, Hench J, Tolnay M, Eckert A, D`Adamo P, Franken P, Ishihara N, Mihara K, Bischofberger J, Scorrano L, Frank S (2016) Synaptic dysfunction, memory deficits and hippocampal atrophy due to ablation of mitochondrial fission in adult forebrain neurons. Cell Death and Differentiation 23: 18-28
D’Adamo P, Masetti M, Bianchi V, Morè L, Mignogna ML, Giannandrea M, Gatti S (2014 available online) RAB GTPases and RAB-interacting proteins and their role in the control of cognitive functions. Neuroscience & Biobehavioral Reviews 46: 302-314
Morè L, Jensen G (2014) Acquisition of conditioned responding in a multiple schedule depends on the reinforcement’s temporal contingency with each stimulus. Learning & Memory 21: 258-262
Schlumberger C, Pietraszek M, Gravius A, Klein K-U, Greco S, Morè L, Danysz W (2009) Comparison of positive allosteric modulator of mGlu5 receptor ADX47273 and mGluR2/3 agonist LY354740 in tests for antipsychotic-like activity. European Journal of Pharmacology, Behavioural Pharmacology section, 623: 73-83
Schlumberger C, Schaefer D, Barberi C, Morè L, Nagel J, Pietraszek M, Schmidt WJ, Danysz W (2009) Effects of a metabotropic glutamate receptor group II agonist LY354740 in animal models of positive schizophrenia symptoms and cognition. Behavioural Pharmacology, 20: 56-66
Morè L (2008) Intra-Female Aggression in the Mouse (Mus musculus domesticus) is linked to the Estrous Cycle Regularity but not to Ovulation. Aggressive Behavior, 34: 46-50
Morè L, Gravius A, Nagel J, Valastro B, Greco S, Danysz W (2008) Therapeutically relevant plasma concentrations of memantine produce significant NMDA receptor occupation and do not impair learning in rats. Behavioural Pharmacology, 19: 724-734
Gravius A, Dekundy A, Nagel J, Morè L, Pietraszek M, Danysz W (2008) Investigation on tolerance development to subchronic blockade of mGluR5 in models of learning, anxiety, and levodopa-induced dyskinesia in rats. Journal of Neural Transmission, 115: 1609-1619
Morè L*, Gravius A*, Pietraszek M, Belozertseva I, Malyshkin A, Shekunova E, Barberi C, Schaefer D, Schmidt WJ, Danysz W (2007) Comparison of the mGluR1 antagonist A-841720 in rat models of pain and cognition. Behavioural Pharmacology, 18: 273-281
Morè L (2006) Mouse Major Urinary Proteins Trigger Ovulation via the Vomeronasal Organ. Chemical Senses, 31: 393-401