Professor Ihtesham ur Rehman
Ihtesham is a leading expert in biomaterials and regenerative medicine, and clinical spectroscopy research and teaching. He has written many seminal publications on spectroscopy of biological tissues, cancer research, multiple sclerosis, synthesis and characterisation of biomaterials, human bone and dental materials. He has given over 100 invited keynote and plenary lectures and developed over 20 undergraduate and postgraduate programmes in biomaterials and regenerative medicine, dental materials and materials science and engineering, which have been recognised internationally.
As Head of Translational Research at the University of Central Lancashire and Director of the Interdisciplinary Centre for Translational Research, Ihtesham’s mission is to save “millions of lives” by improving healthcare through creating innovative technologies for early detection, diagnosis and monitoring of disease by bringing together university and clinical researchers. This is possible by promulgating a successful multidisciplinary approach, moving from concepts of technological solutions to patient care and involving scientists, engineers and clinicians.
As Professor of Biomaterials and Regenerative Medicine in the School, Ihtesham’s ultimate goal is to create an innovation hub for translational research to improve patient care. The hub will bring together researchers across various disciplines from the University, nationally and globally. They will aim to identify new applications of spectroscopy and other analytical techniques, such as loop-mediated isothermal amplification (LAMP) and to explore diagnostic technologies and medical devices for early interventions.
Ihtesham’s diverse research career has spanned over 35 years. He started his research career at the World-renowned Interdisciplinary Research Centre in Biomedical Materials at Queen Mary, University of London and remained there for over 22 years (1988 – 2011). He joined Kroto Research Institute at the University of Sheffield where he established biospectroscopy and dental materials (2011 – 2018). Before joining UCLan in 2023, he moved on to Lancaster University in 2019 and established a strong research group in Biospectroscopy and Bioengineering. From his spectroscopy work on micro-organisms at Lancaster University, he set up a spinout CCI Photonics® to use spectroscopy as a diagnostic tool.
In his career, Ihtesham has developed and overseen over 20 undergraduate and postgraduate programmes in biomaterials and regenerative medicine, dental materials and materials science and engineering. In 2004, the MBA programme, which he devised and managed at Queen Mary University of London (QMUL) was described as one of the most innovative programmes in the country.
Ihtesham has vast experience in Quality Assurance and Enhancement (QAE) including producing subject reviews and accreditation documents. He has more than 14 years of experience in developing and implementing a quality system accredited and registered for ISO9001 and ISO17025. In addition, he devised Standard Operating Procedures (SOPs) for Postgraduate Training and Assessment.
Ihtesham is a Founding Member and was Co-chairman of UPSIGN (UK Pakistan Science and Innovation Global Network) which was set up in 2017. It is an international group of over 250 professionals dedicated to tackling various social and economic challenges that are faced by people of Pakistani origin in Pakistan and the UK. He is also the Executive Director and founder of the Interdisciplinary Research Centre (IRC) in Biomedical Materials, COMSATS, Pakistan doing innovative research in material sciences and life sciences.
Ihtesham has over 300 publications in the fields of spectroscopy of biological tissues, cancer research, early detection and diagnosis, synthesis and characterisation of biomaterials, human bone as well as dental materials (h-index of 62, in Google Scholar, with more than 18 thousand citations).
- Professor of Biomaterials and Regenerative Medicine
- PhD Biomaterials, Queen Mary University of London, 1991
- MSc Chemistry, University of the Punjab, 1986
- BSc Chemistry, University of the Punjab, 1984
- Interdisciplinary research of translational nature
- Clinical spectroscopy
- Biomaterials and regenerative medicine
- Clinical dental materials
- Cancer research; early detection and diagnosis
- Microbes (bacteria, viruses and fungi) and biofilms
- Founding Member and Co-chairman of UPSIGN UPSIGN (UK Pakistan Science and Innovation Global Network)
- Executive Director and Founder IRC in Biomedical Materials, COMSATS, Pakistan
Ihtensham has 302 publications in the fields of spectroscopy of biological tissues, cancer research, early detection and diagnosis, synthesis and characterisation of biomaterials, human bone as well as dental materials (h-index of 62, in Google Scholar, with more than 18 thousand citations). He authored one critically acclaimed book, Vibrational Spectroscopy for Tissue Analysis, and several book chapters. He obtained five patents. Ihtesham has given over 100 invited keynote and plenary lectures in the fields of biomaterials, cancer diagnosis and dental materials.
Ihtesham specialises in multidisciplinary translational research on biomaterials and spectroscopy. He has a strong background in dental materials, biomaterials and spectroscopy of biological molecules. His research interests are multidisciplinary and translational. They include early detection and diagnosis of disease, polymer syntheses, surface modifications, nano-materials, bioceramics, composites and hard/soft tissue engineering scaffolds and drug delivery formulations. His research has focused on biomaterials for regenerative medicine, structural evaluation of biomaterials and analysis of natural tissues and liquid biopsies.
His research covers the following themes:
Spectroscopy for monitoring and diagnosis: His work on spectroscopic cancer analysis has given him international recognition and resulted in two significant review papers on Raman spectroscopy of biological tissues and a monograph, Vibrational Spectroscopy for Tissue Analysis.
Biomaterials for regeneration: Ihtesham worked on developing biomaterials for soft tissue repair and hard tissue replacement. He designed biodegradable low-adherence films to prevent adhesion after surgery, which led to a patent. He also worked on bone analogue materials, and his original articles on FTIR and Raman spectroscopy of bone and hydroxyapatites are still regarded as gold standards in the field of biomaterials.
Dental materials: Ihtesham can be credited with achieving significant progress in introducing bioactivity in dental restorative materials and enhancing their bonding with the tooth structure, which led to the filing of two patent applications.
Bioactive surfaces: Ihtesham’s work on the reaction kinetics of bioactive surfaces by FTIR and Raman spectroscopy helped deepen the understanding of bioactivity and formation of apatite layers on bioactive materials.
Biosensors: Ihtesham has also been involved in developing coatings for sensing applications for optical waveguides (gas sensors, especially oxygen and hydrogen sensors) and successfully obtained two patents.
Ihtesham has registered 5 patents:
- 1994: Biodegradable low adherence films for the prevention of adhesion after surgery
- 2007: Improved optical chemical sensor
- 2007: A porous IPN polymer structure for use in chemical sensing applications
- 2001: A Process for the preparation of carbonated biomedical materials
- 2021: Detection of micro-organisms (bacteria and viruses)
Ihtesham has given over 100 invited plenary lectures, and his webinars, hosted by Thermo Scientific, were delivered to global audiences. He is the editor for Europe of the leading journal of spectroscopy, Applied Spectroscopy Reviews, with a 5-year impact factor of 6.2 (2022).
Use the links below to view their profiles:
- UPSIGN (UK Pakistan Science and Innovation Global Network), Pakistan
- IRC in Biomedical Materials, COMSATS, Pakistan
- Evaluation of Artificial intelligence to Screen & Triage Effectively to Reduce cervical cancer (‘EASTER’), NIH, US, £2,733,775
- Biospectrometry as a non-invasive diagnostic tool for suspected oesophageal cancer, NWCR, £49,893.70
- Rapid Detection of Prostate Cancer Markers using Loop Mediated Isothermal Amplification – Shining light on the prostate cancer pathway, Rosemere, £28,148
- Blindly and independently analyse 700 urine samples from the IARC biobank with the infrared spectroscopy assay to detect the presence of high-risk HPV, IARC/WHO, £15,000
- Developing Raman spectroscopy as a diagnostic tool for prostate cancer – A potential non-invasive alternative to serum PSA (Prostate Specific Antigen) testing and prostate biopsies (October 2021), NWCR, £249,990
- Spectroscopy and Artificial Intelligence to disrupt the status quo in Cervical Cancer Screening (Feb 2022) 12 months, Canadian Cancer Society, CAN $140,483
- CORMIR: Cost-effective Cloud-based Portable Mid-InfraRed Very Rapid detection of COVID (June 2021), Innovate UK, £262,639
- Non-invasive spectroscopic methods to diagnose Colorectal Neoplasia (2020-21)/FAST-Network EPSRC,£62,765
- Advancing the understanding of Biofilms with Raman Spectroscopy, FAST-Network, EPSRC, £50,478
- EPSRC Centre for Doctoral Training in Advanced Biomedical Materials, EPSRC, £6,425,822
- Sheffield Centre for Antimicrobial Resistance and Biofilms (SCARAB) December 2016 [Co-I]
- Innovate UK, £708,000
- Affordable Healthcare for Pakistan – Developing Biomedical Materials for Clinical Impact, Sept 2016 [CoI], GCRF – EPSRC Institutional Sponsorship, £48,885
- Feasibility of using non-invasive Raman Imaging and computational modelling to resolve three-dimensional EPS distribution in biofilms, June 2016 [CoI], SHAMROK, Pump Priming fund, £27,593
- Open-access biomaterials micro-fabrication and non-invasive imaging facilities for Regenerative Medicine Sept 2013, start date April 2014 [CoI], MRC, £730,762
- A Novel Bioactive Functionalised Guided Tissue Regenerative (GTR) Membrane for Periodontal Treatments, Sept 2012 [PI]EPSRC/UoS pump-priming, £32,921
- Functionalised graphene nanoparticles for cancer cell imaging and photothermal therapy Sept 2012 [PI]EPSRC/UoS pump-priming, £34,034
- Mid-infrared swept lasers for intra-operative cancer margin detection; Sept 2012 [CoI]/EPSRC/UoS pump-primin, £37,068
- 3D Tissue Engineered skin, UNITISS, May 2012 [CoI]European Commission, £325,215
- From Laboratory to Pilot Plant; continuous hydrothermal synthesis, (Total Consortium 1 Million) (2006-2009) [CoI]EPSRC, £497,000
- High throughput grant (Nano-discovery project), (2006-2009) [CoI]EPSRC, 8£86,000
- “Healthy Aims” “Implantable micro-sensors and micro-systems for ambulatory measurement and control in medical products (Healthy Aims), Part of Framework 6 European Commission, (2003– 2007) [WP leader], EU, £344,418
- Characterisation of a Novel Bone Cement, Industrial grant, (2007) [PI], Industry, Doxa, Sweden, £12,000
Telephone:+44 (0)1772 895947
Email: Email:Professor Ihtesham ur Rehman
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