Dr Lorenzo More
Senior Lecturer in Neuroscience
School of Pharmacy and Biomedical Sciences
I work in the field of behavioural genetics and molecular cognition. My research final aim is to understand the cellular and molecular mechanisms underlying learning and memory and thus how the brain stores, retrieves and modifies information. I exploit environmental enrichment (EE), which is known to provide the mammal brain with a "cognitive reserve", in pre-clinical models in order to shed light on the complex molecular machinery involved in environment adaptation and enhanced cognition.
Lorenzo recently published on the Journal of Neuroscience and on Behavioural Brain Research about the CNS molecular adaptations to the environment.
Lorenzo More undertook a PhD in Neuroscience at the School of Medicine in Padova in 2005 where he studied the effect of urinary pheromones on ovulation and the role of the olfactory systems. He then worked in Germany, Italy and the UK on preclinical models of Alzheimer’s, Schizophrenia and Parkinson’s disease and since 2011 on the genetic basis of X-linked Intellectual Disabilities and the molecular bases of environmental adaptation. A major development of his recent work on Neuro Developmental Disorders (NDDs), EE and nootropics concerns the identification of a CNS proteomic signature of antisocial traits.
- Fellow of the Higher Education Academy (D2), The University of Warwick (UK), 2017
- Doctor of Research (PhD), Neuroscience, The University of Padova (Italy), 2005
- 5-year Laurea (MSc), Biological Psychology, The University of Padova, 2001
- Merit Pay Award, University of Warwick, 2015
- Neuro Developmental Disorders
- Healthy ageing
- Molecular psychiatry
- Higher Education Academy UK (Fellow D2 level since 02/2017)
- Italian Psychologists’ charter (full member since 03/2004)
- International Behavioural Neuroscience Society
- Topic Editor for Frontiers "Gene and Environment Interactions in Neurodevelopmental Disorders" (ID: 13530)
- Ad-hoc reviewer for the MRC, BBSRC and several peer-reviewed Journals
Living in an enrichment environment with increased levels of physical activity, novelty and a bigger social group has many benefits, one of which is to provide the brain with an enhanced cognitive reserve which is the brain’s resilience to ageing and loss of function. Cognitive reserve is believed to reside into brain neuronal cells and to be functionally exerted as the readiness with which neuronal communication structures called synapses change in shape and function. In our research we describe the key molecular mechanisms by which the brain adapts to environmental enrichment in enhancing learning, memory and synaptic plasticity. This research elucidates the role of a key neuronal protein, MSK1, in response to enrichment and hence paves the way to the identification of molecular targets to pharmacologically induce the beneficial effects of environmental enrichment.
Use the links below to view their profiles:
- View their unique and persistent identifier on the ORCiD registry
- Full list of publications and articles on CLoK
- Google Scholar
- Molecular Psychiatry
- The molecular mechanisms of anti-social behaviours and enhanced cognition
- Recent talks
- Glasgow (UK), June 2020 International Behavioral Neuroscience Society (IBNS) 29th Annual Meeting. The role of the Environment on the Penetrance of Neuro Developmental Disorders, -Oral presentation and Symposium chair, other speakers: Dr Victorio Bambini-Junior, Prof Carmem Gottfried, Dr Lucia Privitera.
- SEALING THE LOOP: Bridging the latest Neuroscience approaches. Edinburg University 7 February 2020. Keynote speaker: Prof Bruno Frenguelli, Notable Speaker: Prof Richard Morris, Guest: Dr Serena Dudek - Oral presentation: Can the emotional valence of stimuli be encoded at a synaptic level ?
- Perugia (Italy), September 2019 Società Italiana Neuro Scienze (SINS) 18th Congress - Oral presentation: Signalling Pathways in Intellectual Disability and Autism Spectrum Disorder: Cellular Mechanisms, Diagnostic Tools and Therapeutic Approaches. Chair: Prof Riccardo Brambilla, co-chair Prof Maurizio Giustetto
- Hiroshima (Japan), June 2017 International Behavioral Neuroscience Society (IBNS) 26th Annual Meeting - Oral presentation and symposium co-chair: Environmental and pharmacological strategies to enhance cognition. Chair: Prof Riccardo Brambilla, other speakers: Dr Julie Lauterborn, Dr Francesco Papaleo