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Electrophysiology Laboratory

Our Electrophysiology Lab investigates the reward circuitry of the brain and how alterations in the function of this circuitry may impact a myriad of atypical behaviour states. We use advanced electrophysiological techniques, animal models and acute slice preparations to achieve this goal. We are currently focused on alterations that may underpin and provide biomarkers for fronto-temporal dementia and Autistic spectrum disorder.

The basal ganglia are a collection of nuclei heavily implicated in action selection and reward related processing. Its main input structure, namely the striatum, is well known to be involved in mediating these processes. Recent evidence suggests that alterations in GABAergic, inhibitory, interneurons in these regions contribute to atypical behavioural states, including several developmental disorders, psychiatric disorders, and degenerative disorders. 

Detailed Information

Kit List

  • Immunohistochemical techniques and equipment
  • Multi-electrode array recording equipment
  • Acute slice preparation equipment
  • Advanced microscopy to visualise and stimulate acute slices
  • We are also currently in the process of setting this up for optogenetic stimulation of acute slice preparations

Availability

Access to the equipment is negotiable, via contact with Dr Clark (mclark11@uclan.ac.uk)

Location

The Electrophysiology Laboratory can be found in DB309 of the Darwin Building

General Enquiry