Chi Ko

Dr. Stan Ko

Senior Lecturer in Medical Sciences

School of Medicine

Harrington Building, HA115.

+44 (0) 1772 89 5877

Stan has a multi-disciplinary biomedical science background and specialises in translational immunology research. His research interests bear a central focus on the role of immune cells in disease initiation and progression including those of cancer and brain injuries. In parallel to his scientific research work, Stan is also keen on developing effective learning and teaching activities in higher education.

Full Profile

Commencing his scientific career as a multi-disciplinary biomedical scientist, Stan gained his Bachelor of Applied Science degree by distant learning and built his expertise in basic and translational immunology at subsequent postgraduate research positions in the Department of Pathology Hong Kong University, University College London’s Institute of Cancer Research in Fulham, the MRC Toxicology Unit at Leicester University and Cambridge University’s MRC Laboratory of Molecular Biology. Stan left Cambridge to enrol on a part time PhD at Leeds University Medical School’s translational research institute, Molecular Medicine Unit, studying the role of macrophages in colorectal cancer progression. Together with similar works generated by a number of other international research groups, his findings contributed to the establishment of a contemporary concept of cancer development: Tumour Associated Macrophage-mediated carcinogenic and metastatic progression. His recent research activities focus on investigating host-immune cell interaction in pathophysiological conditions. Stan’s involvement in undergraduate teaching and postgraduate project supervision nurtured the development of his pedagogic research interests and he commits to promoting quality student learning experience.


Ko, C.W.S. (corresponding author), Cuthbert, R.J., Brooke, D.A., Orsi, N., Coletta, P.L., Perry S.L., Markham, A.F. and Hull, M.A. (2008) Loss of interleukin-4 receptor alpha promotes carcinogen-induced colonic aberrant crypt foci formation in Balb/c mice. Journal of Pathology 214(5): 603-9

Hawcroft, G., Ko, C.W.S. and Hull, M.A. (2007) Prostaglandin E2-EP4 receptor signalling promotes tumorigenic behaviour of HT-29 human colorectal cancer cells. Oncogene 26:3006-19.

Ko, S.C., Chapple, K.S., Hawcroft, G., Coletta, P.L., Markham, A.F. and Hull, M.A. (2002) Paracrine cyclooxygenase-2-mediated signalling by macrophages promotes tumorigenic progression of intestinal epithelial cells. Oncogene 21:7175-86.

Johnson, V.L., Ko, S.C., Holmstrom, T.H., Eriksson, J.E. and Chow, S.C. (2002) Effector caspases are dispensable for the early nuclear morphological changes during chemical-induced apoptosis. Journal of Cell Science 113:2941-53.

Ko, S.C., Johnson, V.L. and Chow, S.C. (2000) Functional characterization of Jurkat T cells rescued from CD95/Fas-induced apoptosis through the inhibition of caspases. Biochemical and Biophysics Research Communications 270:1009-15.


  • Fellow member of the Higher Education Academy
  • Member of the Institute of Biomedical Sciences
  • Member of the British Society for Immunology


  • Host-immune cell interaction in disease pathogenesis
  • The role of Tumour-Associated Macrophage in carcinogenesis and metastasis
  • The impacts of infiltrating immune cells on the modification of tissue microenvironment


  • Higher Certificate in Medical Laboratory Technology (Haematology and Blood Transfusion) Hong Kong 1988
  • BA Medical Laboratory Sciences Charles Sturt Australia 1994
  • PhD Molecular Medicine Leeds UK 2003
  • Teaching Award Professional Standard Level 2 Leeds UK 2011

Teaching responsibilities and activities

Bachelor of Science (Hons) in Medical Sciences
Years 1 and 2 Lead
Module lead - Molecular Medicine, Immunology

Bachelor of Dental Surgery
Module lead - Human Health and Disease 1

Bachelor of Medicine, Bachelor of Surgery
Module lead - Evidence-Informed Practice of Medicine

Members of committees and reviewing panels
MB BS curriculum implementation team
MBBS Equality and Diversity Lead
BSc (Hons) Medical Sciences curriculum design team

University of Central Lancashire e-ethics committee
School of Medicine and Dentistry ethics committee
School of Medicine and Dentistry Human Tissue Act Lead

Scientific advisory board member of Journal of Contemporary Medical Education



Ko C.W.S (Corresponding author)., Topham C., Jameson R., Williams J., McCarthy R., Chamberlain H., Walker J., Simpson N. Modulation of macrophage pro-inflammatory mediator expression by the progestagens medroxyprogesterone acetate and 17-alpha- hydroxyprogesterone caproate. British Society for Immunology Regional Conference Yorkshire Immunology Group 2013

Al-Hirmizy D., Nugent D., Ko S., Duffy S., Wood N. Length of hospital stay Post-operatively is not decreased by pre-operative oral carbohydrate administration in patients with advanced ovarian cancer undergoing surgery. European Society for Gynaecological Oncology Conference 2013

Davies P., Simpson N., Ko C.W.S. (Corresponding author) Foxp3 single nucleotide polymorphisms as key genetic predisposing factors in preeclampsia – a pilot population study. National Perinatal Conference 2012

Booth, S; Wood, N; Ko, S; Nugent, D; Duffy, S; AL-Hirmizy, D. A randomised control trial of pre-operative oral carbohydrates administration in patients undergoing surgery for advanced stage ovarian cancer. International Conference on Ovarian Screening 2011

Beder D., Simpson N., Ko S. (Corresponding author). Macrophage-conditioned medium culture model for the investigation of fetomaternal interface infections-associated neonatal brain injuries. Frontiers in Cell Biology and Medicine 2010

Al-Hirmizy D., Wood N., Nugent D., Ko S., Duffy S. The effects of pre-operative carbohydrates loading on immunological parameters of ovarian cancer patients undergoing hysterectomy – preliminary data on a randomised controlled trial. Yorkshire Cancer Network regional meeting 2009


The use of serial student peer reviews as multi-purpose facilitator in the learning process of first year medical students. Student Education Conference 2014