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Dr Inma González

Dr. Inma González

Lecturer

School of Pharmacy and Biomedical Sciences

Maudland Building, MB137

+44 (0) 1772 89 3503

MGonzalez3@uclan.ac.uk

Subject Areas: Biosciences

Full Profile

Dr González completed her Ph.D. in Neurobiochemistry at the Centre for Molecular Biology "Severo Ochoa" (CBMSO, Spain). Her work, focused on the study of monoamines transporters, supported the existence of the “neuronal” glutamate transporter GLT1 and characterized the role of two low affinity transporters, SNAT5 and SNAT2, in the glutamate-glutamine cycle in the CNS.  She undertook an EMBO postdoctoral fellowship with Professor Jeremy Henley (Bristol University), to apply live imaging techniques to the study of neurotransmitters receptors trafficking. Her studies in this area were the initial step to discover the role of Kainate receptors (KAR) in the induction of a novel form of LTP (KAR-LTP). Moving to the Interdisciplinary Institute of Neuroscience (IINs, Bordeaux) with Professor Christophe Mulle, she continued working on the role of KAR in memory and cognition (FENS fellowship). At the IINs, Inma worked with Laurent Groc on the role of the non-conventional GluN3A NMDAR subunit in the synaptic stabilization of NMDAR through their lateral diffusion. The preliminary data was the basis for a project awarded with a Marie-Curie fellowship (CIMA, Spain). In 2015, Inma worked closely with Ladislav Vyklicky (Academy of Science, Czech Republic) in different aspects of NMDAR trafficking regulation. Moving back to the UK Inma undertook a Lecture position in the School of Pharmacology and Biomedical sciences (UCLan) were she is developing her research interests on neurotransmitters receptors trafficking, memory and cognition.

Qualifications:

  • B.Sc Biology (specialization in Molecular Biology), Universidad Autónoma de Madrid , 2002
  • B.Sc Biochemistry, Universidad Autónoma de Madrid , 2002
  • PhD Neuroscience, Universidad Autonoma de Madrid, 2007

Publications

Petrovic M, Silva S, Vyklický L., Mulle C, Gonzalez-Gonzalez IM*, Henley JM,*. Postsynaptic kainate receptor-dependent hippocampal LTP. Nature Neuroscience (online publication Feb 2017). (*co-corresponding and co-last authors)

Chamberlain SE*, Gonzalez-Gonzalez IM*, Konopacki F, Wilkinson KA, Henley JM, Mellor JR. SUMOylation and phosphorylation of the kainate receptor subunit GluK2 regulate kainate receptor trafficking and synaptic plasticity. Nature Neuroscience 15(6):845-52 (2012). (*First co-authors).

Kantamneni S*, Gonzàlez-Gonzàlez IM*, Luo J, Cimarosti H, Jacobs SC, Jaafari N, Henley JM. Differential regulation of GABAB receptor trafficking by different modes of Nmethyl-D- aspartate (NMDA) receptor signaling. J Biol Chem 7;289(10):6681-94 (2014). (*First co-authors)

Gonzalez-Gonzalez IM, Henley JM. Metabotropic autoregulation of postsynaptic kainate receptor recycling and surface expression. Traffic 14(7):810-22 (2013)

Gonzalez-Gonzalez IM, Jaskolski F, Goldberg Y, Ashby MC, Henley JM. Measuring membrane protein dynamics in neurons using fluorescence recovery after photobleach. Methods Enzymol. 504:127-46 (2012)

Fiuza M, González-González I, Pérez-Otaño I. GluN3A expression restricts spine maturation via inhibition of GIT1/Rac1 signaling. PNAS, 17;110(51):20807-12 (2013)

Research

Neurotransmitter receptor trafficking in plasticity and disease

Membership of professional and learned bodies

  • 2017  Guest Associate Editor, Frontiers in Molecular Neuroscience.
  • 2017  British Neuroscience Association.
  • 2014  Guest Associate Editor, Frontiers in Cellular Neuroscience.
  • 2010 – to date: Society of Spanish Researchers in the UK (SRUK).
  • 2004 – to date: Spanish Society for Biochemistry and Molecular Biology (SEBBM). Constituent society of FEBS.

Projects

Neurotransmitter receptor trafficking in plasticity and disease:

Neurotransmitter receptor insertion and removal to and from synapsis underlie many forms of experience-dependent plasticity including learning and memory. Understanding the processes that controls the surface expression, maintenance and dynamics of neurotransmitter receptors is key to stablish the cellular and molecular basis of the excitatory transmission and synaptic plasticity in memory, cognition and normal brain function.

My research is focus on the mechanisms by which neurotransmitter receptors are targeted to, retained at and removed from the synapses under normal, stimulated and pathological conditions.

A profound understanding of the mechanisms ruling this processes will give important insights into synapse formation, stabilisation and plasticity and thus into the cellular mechanisms underlying learning and memory and some neurodegenerative diseases.

To address these questions we use a wide range of molecular, biochemical, electrophysiological and cutting-edge imaging techniques to visualise the dynamics of receptor movement in living neurones in real time.

Contact me if you are interested in being part of the team!

Teaching activities and responsibilities

Lecturer for the School of Pharmacy and Biomedical Sciences

Conferences

  1. 44th Annual Meeting of the Society for Neuroscience 2014 (Washinton, USA). GonzalezGonzalez, IM, Gray J, Bard L, Bouchet D, Nicol R, Groc L, Perez-Otano, I. GluN3A expression modulates the synaptic stabilization of NMDAR through their lateral diffusion.
  2. Workshop Universidad Internacional de Andalucia “Membrane Traffic at the Synapse. The Cell Biology of Synaptic Plasticity”. Baeza, Spain. 2013.
  3. FENS Congress 2013: FENS Featured Regional Meeting, Prague, Czech Republic.
  4. International Symposium on frontiers in ion channels research (SICI-Consolider). 2012.. Segovia, Spain.
  5. International Symposium on Ionotropic Glutamate Receptors, Physiology, Pathology and Therapeutics, 2012. Agonist-dependent kainate receptor endosomal trafficking and recycling in dendritic spines. Gonzalez-Gonzalez MI., Petrovic M. and Henley J.M. Valencia, Spain.
  6. EMBO workshop 2011. Cell Biology of the Neuron: Polarity, Plasticity and Regeneration Mechanisms controlling the number and location of synaptic KARs. Gonzalez-Gonzalez MI., Petrovic M. and Henley J.M. Heraklion, Greece.
  7. FENS 2010, Mechanisms controlling the number and location of synaptic KARs. GonzalezGonzalez MI., Chamberlain S.E.L., Mellor J. R. and Henley J.M. Amsterdam, Holland 2010.
  8. Invited department seminar at the Max Planck Institute for Brain Research neuroscience (Prof. H. Betz), Frankfurt, Germany 2009.
  9. SEBBM 2008. GLT1a interacts with PSD95 through the heterooligomeric assembly with GLT1b. M Inmaculada Gonzalez, Gordo-Gilart R, Cecilio Gimenez y Francisco Zafra. Bilbao, Spain 2008.
  10. SEBBM 2007. The ubiquitinilation system regulate the biogenesis and degradation of the glutamate transporter GLT1. M Inmaculada Gonzalez, Noemi Garcia, Cecilio Gimenez y Francisco Zafra. Malaga, Spain 2007.
  11. SEBBM 2007. The PKC regulated endocytosis of the glutamate transporter GLT1a depends of the ubiquitination system. Noemi Garcia, M Inmaculada Gonzalez, Cecilio Gimenez y Francisco Zafra. Malaga, Spain, 2007. Fisher Award
  12. SEBBM 2005. The glutamate transporter EAAT2 interacts with PDZ domain proteins. Role of PSD95 in the delivery and endocytosis of EAAT2. Inmaculada Gonzalez, Cecilio Giménez y Francisco Zafra. Zaragoza, Spain, 2005.
  13. SEBBM 2004. The aminoacid transporters SN2 y ATA2 show a differential distribution in de nervous system cells. Inmaculada González, Beatriz Cubelos, Cecilio Gimenez y Francisco Zafra. Lerida, Spain, 2004.
  14. SEBBM 2003. The glycine transporter GLYT1 interacts with PSD95 and impairs its internalization. Beatriz Cubelos, Inmaculada Gonzalez, Cecilio Gimenez y Francisco Zafra. Coruña, Spain, 2003.