School of Pharmacy and Biomedical Sciences
Maudland Building, MB137
+44 (0) 1772 89 3503
Subject Areas: Biosciences
Dr González completed her Ph.D. in Neurobiochemistry at the Centre for Molecular Biology "Severo Ochoa" (CBMSO, Spain). Her work, focused on the study of monoamines transporters, supported the existence of the “neuronal” glutamate transporter GLT1 and characterized the role of two low affinity transporters, SNAT5 and SNAT2, in the glutamate-glutamine cycle in the CNS. She undertook an EMBO postdoctoral fellowship with Professor Jeremy Henley (Bristol University), to apply live imaging techniques to the study of neurotransmitters receptors trafficking. Her studies in this area were the initial step to discover the role of Kainate receptors (KAR) in the induction of a novel form of LTP (KAR-LTP). Moving to the Interdisciplinary Institute of Neuroscience (IINs, Bordeaux) with Professor Christophe Mulle, she continued working on the role of KAR in memory and cognition (FENS fellowship). At the IINs, Inma worked with Laurent Groc on the role of the non-conventional GluN3A NMDAR subunit in the synaptic stabilization of NMDAR through their lateral diffusion. The preliminary data was the basis for a project awarded with a Marie-Curie fellowship (CIMA, Spain). In 2015, Inma worked closely with Ladislav Vyklicky (Academy of Science, Czech Republic) in different aspects of NMDAR trafficking regulation. Moving back to the UK Inma undertook a Lecture position in the School of Pharmacology and Biomedical sciences (UCLan) were she is developing her research interests on neurotransmitters receptors trafficking, memory and cognition.
Petrovic M, Silva S, Vyklický L., Mulle C, Gonzalez-Gonzalez IM*, Henley JM,*. Postsynaptic kainate receptor-dependent hippocampal LTP. Nature Neuroscience (online publication Feb 2017). (*co-corresponding and co-last authors)
Chamberlain SE*, Gonzalez-Gonzalez IM*, Konopacki F, Wilkinson KA, Henley JM, Mellor JR. SUMOylation and phosphorylation of the kainate receptor subunit GluK2 regulate kainate receptor trafficking and synaptic plasticity. Nature Neuroscience 15(6):845-52 (2012). (*First co-authors).
Kantamneni S*, Gonzàlez-Gonzàlez IM*, Luo J, Cimarosti H, Jacobs SC, Jaafari N, Henley JM. Differential regulation of GABAB receptor trafficking by different modes of Nmethyl-D- aspartate (NMDA) receptor signaling. J Biol Chem 7;289(10):6681-94 (2014). (*First co-authors)
Gonzalez-Gonzalez IM, Henley JM. Metabotropic autoregulation of postsynaptic kainate receptor recycling and surface expression. Traffic 14(7):810-22 (2013)
Gonzalez-Gonzalez IM, Jaskolski F, Goldberg Y, Ashby MC, Henley JM. Measuring membrane protein dynamics in neurons using fluorescence recovery after photobleach. Methods Enzymol. 504:127-46 (2012)
Fiuza M, González-González I, Pérez-Otaño I. GluN3A expression restricts spine maturation via inhibition of GIT1/Rac1 signaling. PNAS, 17;110(51):20807-12 (2013)
Neurotransmitter receptor trafficking in plasticity and disease:
Neurotransmitter receptor insertion and removal to and from synapsis underlie many forms of experience-dependent plasticity including learning and memory. Understanding the processes that controls the surface expression, maintenance and dynamics of neurotransmitter receptors is key to stablish the cellular and molecular basis of the excitatory transmission and synaptic plasticity in memory, cognition and normal brain function.
My research is focus on the mechanisms by which neurotransmitter receptors are targeted to, retained at and removed from the synapses under normal, stimulated and pathological conditions.
A profound understanding of the mechanisms ruling this processes will give important insights into synapse formation, stabilisation and plasticity and thus into the cellular mechanisms underlying learning and memory and some neurodegenerative diseases.
To address these questions we use a wide range of molecular, biochemical, electrophysiological and cutting-edge imaging techniques to visualise the dynamics of receptor movement in living neurones in real time.
Contact me if you are interested in being part of the team!
Lecturer for the School of Pharmacy and Biomedical Sciences