Dr. Sim K. Singhrao

Dr. Sim K. Singhrao

Senior Research Fellow

School of Dentistry

Harrington Building, Room 132

+44 (0) 1772 89 5137

Subject Areas: Dentistry

Sim is a cell biologist with a special interest in neurosciences, innate immunology and microbiology of biofilms on clinical devices. Sim has extensive hands-on bio-medical research experience and her main interest lies in finding how chronic periodontitis may be a risk factor for a multitude of distant organ diseases in relation to neurodegeneration and translational devices for direct and/or indirect patient benefit.

Sim is research active within the area of medicine and dentistry and is a member of the Oral Dental Sciences Research Group.

Full Profile

Work experience

Dr Sim K. Singhrao C Biol, MI Biol, M Phil, PhD, FHEA., PG Cert

Sim's postgraduate education and training began in the School of Medicine, Cardiff University, Wales, UK. Whilst working closely with consultant neuropathologists, she became interested in neurodegenerative diseases especially Alzheimer's disease, Pick's disease and Huntington's disease. The inflammatory component of these diseases directed her to explore the role of innate immune responses in demented brains. These projects provided collaborative opportunities with centres of excellence, eg The Karolinska institute (Sweden) and Brussels (Biotechnology-SME).

Sim has expertise in many areas of medical and dental sciences research bringing a wealth of knowledge to explore diverse innovative research projects related to periodontal disease(s) and its putative links with dementia. This research has led to unique opportunities to collaborate with top scientists for our cutting edge innovative research with potential for improving health and/or to treat or delay onset of neurodegenerative diseases. This research is being strengthened by studies involving animal models of periodontal disease via an international collaboration with Professor L. Kesavalu (University of Florida, USA) and human brain specimens from “Brains for Dementia Research” and prospective clinical studies with Prof. Ingar Olsen, University of Oslo, Norway.

Dr Singhrao is looking for potential self-funding graduates for undertaking MSc by research (1 year full time) in the subject of oral health and Alzheimer’s disease research. Further enquiries can be made by contacting Dr Singhrao directly using the e-mail or phone number provided above. 


Olsen I, Singhrao SK (2015) Can oral infection be a risk factor for Alzheimer’s disease? J Oral Microbiol 7: 29143. Review -

Singhrao SK, Harding A, Simmons T, Robinson S, Kesavalu L, Crean StJ (2014) Oral inflammation, tooth loss, risk factors and association with progression of Alzheimer’s disease. J Alzheimers Dis. 1;42(3):723-37

Poole S, Singhrao SK, Chukkapalli S, Rivera M, Velsko I, Kesavalu L, Crean StJ (2015) Active invasion of an oral bacterium and infection-induced complement activation in ApoEnull mice brains. J Alzheimers Dis. 43: 67–80.

Poole S, Singhrao SK, Kesavalu L, Curtis MA, Crean S (2013) Determining the presence of periodontopathic virulence factors in short-term post-mortem Alzheimer’s disease brain tissue. J Alzheimers Dis 36(4):665-77.

More publications

Research Activities

Sim's main research area is investigating etiological links with a number of chronic inflammatory diseases of distant organs involving dental pathogens, eg Periodontal disease, stroke, diabetes, and dementia.

Research Projects

Aetiological links between oral pathogens and Alzheimer's disease,

Changes in oral flora in acute phase stroke patients,

Ecology of dental-unit waterlines,

Clinical implications and development of interventional devices to monitor and control microbial contamination.


Fellow of Higher Education Academy

External Activities

Academic prizes: Tudor Wood Davies Memorial Prize for beginners in science (Cardiff University).

Recipient of the 2011, Don Claugher Bursary prize which was awarded by the Committee of the Society of Electron Microscope Technology.

Associate Editor for the Journal of Alzheimer's Disease 2014.

Teaching Activities and Responsibilities

Duties include managing the Oral and Dental Sciences Research Group (ODSRG). Placing bids for external funding, supervising research staff and postgraduate students registered for MRes, MPhil and PhD. Responding to the daily needs of overall research projects and staff. Help students with their study plan, check progress is being made towards their set goals and making sure they gain the specific skills needed to be independent researchers through group meetings, tutorials and general guidance on ad hoc basis. The newly gained teaching qualifications have enabled Sim to deliver research informed teaching to undergraduate dental courses.


British Neuropathology Society (BNS), Alzheimer's disease Society, Cardiff Institute of tissue Engineering and repair (CITER), British Society for matrix Biology (BSMB), Tissue & Cell Engineering Society (TCES).


Plenary speaker at the 2015 Alzheimer’s Disease Congress, London, UK

And Guest speaker at the annual international symposium on oral bioscience, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.

And Alzheimer’s Research UK, conference 2015