School of Pharmacy and Biomedical Sciences
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Subject Areas: Biosciences
Vassilis Beglopoulos is a neuroscientist and molecular biologist. His main research interest is the study of experimental models of Alzheimer’s disease, using behavioural, biochemical, molecular and histological approaches. He is particularly interested in the cellular mechanisms underlying impairment of memory retrieval in pre-pathological experimental models of Alzheimer’s disease. His PhD has been on the role of the synaptic proteins neurexophilins in the brain by generating and analysing knock-in and knockout models.
Vassilis Beglopoulos graduated from the University of Thessaloniki in Greece with a BSc in Chemistry/Biochemistry and continued his studies in the UK, graduating with an MSc in Molecular Biology and Biotechnology from the University of Hull. He then went on to use Molecular Biology / Biochemistry in Neuroscience research for his PhD, and later to work on further aspects of Neuroscience research as postdoctoral fellow, in particular behavioural testing, histological approaches and glucose uptake physiology.
Vassilis undertook a PhD at the University of Göttingen in Germany, working with Prof. Markus Missler on the role of the synaptic protein family neurexophilins in the brain by generating and analysing knock-in and knockout experimental models. He then moved to Harvard University, in Boston, USA, working as postdoctoral fellow with Prof. Jie Shen on the role of presenilins in Alzheimer’s disease, using a variety of knockout and knock-in models. Vassilis later worked with Prof. Noel Buckley at King’s College London on the epigenetics of the central nervous system, and then moved to the University of Edinburgh, where he worked with Prof. Richard Morris on developing a cognitive/physiological biomarker strategy in an experimental model of Alzheimer’s disease, based on the early detection of cryptic deficits in memory retrieval and associated brain glucose uptake.
Since joining UCLan in 2017 as Lecturer in Neuroscience, Vassilis is a member of the Neurodegeneration Research Group within the Neuroscience theme, and has been enjoying fruitful interaction with numerous colleagues at UCLan active in Neuroscience research, using a wide variety of methodologies. Vassilis is interested in various aspects of research on Alzheimer’s disease and certain other conditions, with a particular focus on the cellular mechanisms underlying impairment of memory retrieval in pre-pathological experimental models of Alzheimer’s disease.
Vassilis’ research is funded by a grant from the Royal Society and by start-up funds from the University of Central Lancashire.
Beglopoulos V, Tulloch J, Roe AD, Daumas S, Ferrington L, Watson R, Fan Z, Hyman BT, Kelly PAT, Bard F, and Morris RGM. (2016) Early detection of cryptic memory and glucose uptake deficits in pre-pathological APP mice. Nature Communications 7:11761, 1-10.
Zhang C, Wu B, Beglopoulos V, Wines-Samuelson M, Zhang D, Dragatsis I, Südhof TC, and Shen J (2009) Presenilins are essential for regulating neurotransmitter release. Nature 460, 632-636.
Beglopoulos V, Montag-Sallaz M, Rohlmann A, Piechotta K, Ahmad M, Montag D, and Missler M (2005) Neurexophilin 3 is highly localized in cortical and cerebellar regions and is functionally important for sensorimotor gating and motor coordination. Molecular and Cellular Biology 25, 7278-7288.
Beglopoulos V, Sun X, Saura CA, Lemere CA, Kim RD, and Shen J (2004) Reduced beta-amyloid production and increased inflammatory responses in presenilin conditional knock-out mice. Journal of Biological Chemistry 279, 46907-46914.
Cellular mechanisms underlying impairment of memory retrieval in pre-pathological experimental models of Alzheimer’s disease
Vassilis has produced a One Minute Research video about his research into Alzheimer’s disease, in particular the mechanisms underlying the decline of memory in two experimental models of the disease
PJ1301 Health and Disease
BL2217 Systems Pharmacology
PJ2300 Systems-Based Patient Care 1
BL3299 Research Projects
PJ3997 Research Methods and Project Development
BL3220 Advanced Systems Pharmacology
BL4203 Biomedical Ethics