School of Pharmacy and Biomedical Sciences
Darwin Building, DB344
+44 (0) 1772 89 4475
Sarah is research active within the area of nanotechnology and bioengineering. She is a member of the Molecular Biophysics research group.
Sarah Dennison is a Research Associate in the School of Pharmacy and Biomedical Sciences. After graduating from University of Wales, Bangor in Environmental Biology in 1999, Sarah undertook postgraduate research in biochemistry/biophysics. Sarah has spent the last seven years investigating the biological activity of antimicrobial peptides using an number of techniques such as Langmuir Blodgettry and antimicrobial assays. Sarah has produced over 23 publications and 37 conference proceedings from her PhD research and parallel collaborative work.
BSc (Hons) Environmental Biology , University of Wales, Bangor, UK
PhD – Investigation into the structure function relationship of the membrane interaction of amphiphilic alpha helical antimicrobial peptides.
Dennison, Sarah Rachel, Phoenix, Adam J and Phoenix, David Andrew (2012) Effect of salt on the interaction of Hal18 with lipid membranes. European Biophysics Journal, 41 (9). pp. 769-776. ISSN 0175-7571
Mura, Manuela, Dennison, Sarah Rachel, Zvelindovsky, Andrei V. and Phoenix, David Andrew (2013) Aurein 2.3 functionality is supported by oblique orientated α-helical formation. Biochimica et Biophysica Acta (BBA) - Biomembranes, 1828 (2). pp. 586-594. ISSN 00052736
Dennison, Sarah Rachel, Morton, Leslie Hugh Glyn, Shorrocks, Andrea Julie, Harris, Frederick and Phoenix, David Andrew (2009) A study on the interactions of Aurein 2.5 with bacterial membranes. Colloids and Surfaces B Biointerfaces, 68 (2). pp. 225-230. ISSN 09277765
Dennison, Sarah Rachel, Harris, Frederick, Morton, Leslie Hugh Glyn and Phoenix, David Andrew (2013) Antimicrobial activity of aurein 2.5 against yeasts. FEMS Microbiology Letters, 346 (2). pp. 140-145. ISSN 03781097
Our research group is headed by Professor D. A Phoenix. The main focus of our research is the characterization of the biological activities of amphiphilic molecules. We have a specialised interest in antimicrobial/anticancer peptides. Our laboratory is currently pursuing a number of questions concerning the mechanism of action of these peptides. The research involves both theoretical investigations and practical based laboratory work. The group has developed a range of techniques and specialises in Langmuir Blodgett troughs. Our laboratory has a number of Langmuir troughs, which allows a highly flexible approach to the study of membrane interactive molecules in terms of model membrane composition, subphase pH, ionic strength and other factors. Monolayers have been used to mimic bacterial and tumour cell membranes to investigate the peptide lipid interactions.
Investigation of the mechanisms of antimicrobial activity of cationic and anionic antimicrobial peptides
Anticancer α-helical peptides and structure / function relationships underpinning their interactions with tumour cell membranes
Institute of Biology 1995 Chartered
Biochemical Society 1999 Member
The British Biophysical Society 2001 Graduate
Biophysics Society 2006 Graduate