Dr. Sim K. Singhrao

Dr. Sim K. Singhrao

Senior Research Fellow

School of Dentistry

Harrington Building, Room 132

+44 (0) 1772 89 5137


Subject Areas: Dentistry

Sim is a cell biologist with a special interest in neurosciences, innate immunology and microbiology of biofilms on clinical devices. Sim has extensive hands-on bio-medical research experience and her main interest lies in finding how chronic periodontitis may be a risk factor for a multitude of distant organ diseases in relation to neurodegeneration and translational devices for direct and/or indirect patient benefit.

Sim is research active within the area of medicine and dentistry and is a member of the Oral Dental Sciences Research Group.

Full Profile

Work experience

Dr Sim K. Singhrao C Biol, MI Biol, M Phil, PhD, FHEA., PG Cert

Sim's postgraduate education and training began in the School of Medicine, Cardiff University, Wales, UK. Whilst working closely with consultant neuropathologists, she became interested in neurodegenerative diseases especially Alzheimer's disease, Pick's disease and Huntington's disease. The inflammatory component of these diseases directed her to explore the role of innate immune responses in demented brains. These projects provided collaborative opportunities with centres of excellence, eg The Karolinska institute (Sweden) and Brussels (Biotechnology-SME).

Sim has expertise in many areas of medical and dental sciences research bringing a wealth of knowledge to explore diverse innovative research projects related to periodontal disease(s) and its putative links with dementia. This research has led to unique opportunities to collaborate with top scientists for our cutting edge innovative research with potential for improving health and/or to treat or delay onset of neurodegenerative diseases. This research is being strengthened by studies involving animal models of periodontal disease via an international collaboration with Professor L. Kesavalu (University of Florida, USA) and human brain specimens from “Brains for Dementia Research” and prospective clinical studies with Prof. Ingar Olsen, University of Oslo, Norway.

Dr Singhrao is looking for potential self-funding graduates for undertaking MSc by research (1 year full time) in the subject of oral health and Alzheimer’s disease research. Further enquiries can be made by contacting Dr Singhrao directly using the e-mail or phone number provided above. 

Sim had an article published on The Conversation in January 2019 about the link between Alzheimer’s disease and gum disease, entitled ‘Alzheimer’s is linked to gum disease – but bad oral health is not the only culprit’


Olsen, Ingar and Singhrao, Simarjit Kaur (2015) Can oral infection be a risk factor for Alzheimer’s disease? Journal of Oral Microbiology, 7 . ISSN 2000-2297

Harding, Alice, Robinson, Sarita Jane, Crean, Stjohn and Singhrao, Simarjit Kaur (2017) Can better management of periodontal disease delay the onset and progression of Alzheimer’s disease? Journal of Alzheimer’s Disease . ISSN 1387-2877

Poole, Sophie, Singhrao, Simarjit Kaur, Chukkapalli, Sasanka, Rivera, Mercedes, Velsko, Irina, Kesavalu, Lakshmyya and Crean, Stjohn (2015) Active invasion of Porphyromonas gingivalis and infection-induced complement activation in ApoE-/- mice brains. Journal of Alzheimer's Disease, 43 (1). pp. 67-80. ISSN 1387-2877

Poole, Sophie, Singhrao, Simarjit Kaur, Kesavalu, Lakshmyya, Curtis, Michael A. and Crean, Stjohn (2013) Determining the Presence of Periodontopathic Virulence Factors in Short-Term Postmortem Alzheimer's Disease Brain Tissue. Journal of Alzheimer's Disease, 36 (4). p. 665. ISSN 1387-2877

More publications

Research Activities

Sim's main research area is investigating etiological links with a number of chronic inflammatory diseases of distant organs involving dental pathogens, eg Periodontal disease, stroke, diabetes, and dementia.

Research Projects

Aetiological links between oral pathogens and Alzheimer's disease,

Changes in oral flora in acute phase stroke patients,

Ecology of dental-unit waterlines,

Clinical implications and development of interventional devices to monitor and control microbial contamination.


Fellow of Higher Education Academy

External Activities

Academic prizes: Tudor Wood Davies Memorial Prize for beginners in science (Cardiff University).

Recipient of the 2011, Don Claugher Bursary prize which was awarded by the Committee of the Society of Electron Microscope Technology.

Associate Editor for the Journal of Alzheimer's Disease 2014.

Teaching Activities and Responsibilities

Duties include managing the Oral and Dental Sciences Research Group (ODSRG). Placing bids for external funding, supervising research staff and postgraduate students registered for MRes, MPhil and PhD. Responding to the daily needs of overall research projects and staff. Help students with their study plan, check progress is being made towards their set goals and making sure they gain the specific skills needed to be independent researchers through group meetings, tutorials and general guidance on ad hoc basis. The newly gained teaching qualifications have enabled Sim to deliver research informed teaching to undergraduate dental courses.


  • British Neuropathology Society (BNS), Alzheimer's disease Society, Cardiff Institute of tissue Engineering and repair (CITER), British Society for matrix Biology (BSMB), Tissue & Cell Engineering Society (TCES).
  • Plenary speaker at the 2015 Alzheimer’s Disease Congress, London, UK
  • And Guest speaker at the annual international symposium on oral bioscience, Faculty of Dental Science, Kyushu University, Fukuoka, Japan.
  • And Alzheimer’s Research UK, conference 2015
  • Dr Singhrao has been invited to share her subject knowledge by giving a platform presentation at the International Conference and Public Debate on Chronic Inflammatory Diseases, specifically ALZHEIMER’S DISEASE.  It will be held at the Regent Convention centre on the 10-13th October, 2018, Switzerland.  The title of her presentation is ‘Prevention/delay onset of Alzheimer’s disease from an oral health/healthy living perspective’ and Sim will specifically be speaking about the role of gum disease causing bacteria as a risk for developing Alzheimer’s disease. The conference will also focus on Lime disease which can also leads to dementia and other neurological, psychiatric and chronic inflammatory disorders following chronic infections. The action plan is to face the challenge of behaviour in the demented and putative treatments/prevention/disease management, in the context of modifiable risk factors, during early life.  The conference speakers include international scientists working on the infection model of Alzheimer’s disease in the presence of European Union politicians.