Transcutaneous Posterior Tibial Nerve Stimulation (TPTNS) for Rehabilitation And Treatment for Urinary Incontinence.


Stroke related urinary incontinence (UI) persists in more than one-third of stroke survivors and is associated with reduced quality of life, increased morbidity and disability. Urgency UI, together with overactive bladder (OAB) symptoms (frequency, urgency, nocturia), is most commonly experienced. Current continence care is limited to lifestyle advice and behavioural interventions, with a lack of available options for active treatment.

TREAT-UI is a pilot randomised controlled trial to test the effectiveness of transcutaneous posterior tibial nerve stimulation to alleviate stroke-related bladder dysfunction


The trial aims to:

Assess whether a programme of TPTNS has the potential to be effective and cost-effective in reducing the number of episodes and severity of urinary incontinence; symptoms of urinary urgency, frequency, nocturia (the need to wake and pass urine at night) and retention, and what sample size would be required to definitively evaluate this in a full-scale trial

Assess whether a trial of TPTNS for stroke-related urinary incontinence is feasible in terms of rates of participant recruitment and retention, acceptability of the intervention, occurrence of adverse events, fidelity to the intervention and choice of primary and secondary outcome measures.

Project Lead/Contact

  • Professor Joanne Booth, Glasgow Caledonian University
  • Dr Chris Sutton, Lancashire Clinical Trials Unit

Project Staff

  • Dr Mal Auton, Lancashire Clinical Trials Unit
  • Jane Burnell, Lancashire Clinical Trials Unit
  • Alison Hadley, Lancashire Clinical Trials Unit
  • Laura Howell, Lancashire Clinical Trials Unit

Collaborators and Partners

  • Glasgow Caledonian University

Clients or Funders

  • The Stroke Association