In general, lipid biomembranes are responsible for structuring and compartmentalization of cells and subcellular organelles.
Many important functions are performed cooperatively with membrane proteins, for example, signal transmission, cell differentiation and fusion, protection and insulation of important organs, and biomolecular transport across membranes.
We study interactions of various biomolecules, including membrane proteins, with planar and complex biomembranes formed of lipid nanostructures to help the understanding of some of the above functions.
Biomolecules Altering the Lipid Molecular Shape in Model Non-Lamellar Membranes Kulkarni,C.V*, Y. Patil-Sen, M.V. Kulkarni and A. Iglic (2015) Biophys. J, 108 (2) Supplement 1 p544a.
Pressure Effects on a Protein-Lipid Model Membrane Kulkarni, C.V.*, O. Ces, R. H. Templer and J. M. Seddon* (2013) Soft Matter, 9 (28), 6525 - 6531
Lipid Nanobilayers to Host Biological Nanopores for DNA Translocations K. Göpfrich, C.V. Kulkarni, O.J. Pambos and U.F. Keyser* (2013) Langmuir 29: 355-364
Monoolein: Magic Lipid? Kulkarni, C.V.*, W. Wachter, G. R. Iglesias, S. Engelskirchen and S. Ahualli (2011) Phys. Chem. Chem. Phys., 13 (8): 3004-3021
In Cubo Crystallization of Membrane Proteins Kulkarni, C.V.* (2010) Advances in Planar Lipid Bilayers and Liposomes, Vol.12, Chapter 9, 237-272, Ed. A. Iglic, Academic Press
Evidence That Membrane Curvature Distorts the Tertiary Structure of Bacteriorhodopsin Kulkarni, C.V., A. M. Seddon, O. Ces, and R. H. Templer.* (2010) Soft Matter, 6: 4339-4341