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Professor Janusz Jankowski

Prof. Janusz Jankowski

Pro Vice Chancellor (Research) and Professor of Medicine

School of Medicine

Adelphi Building, AB222

+44 (0) 1772 89 6340

jjankowski@uclan.ac.uk

Subject Areas: Basic, Translational and Applied Clinical Research, Multi- and Trans-disciplinary Research, Research Governance, Research Quality and Funding.

Janusz is a member of

  • Senior Management Team
  • School of Medicine
  • Clinical Executive Group (NHS).

Full Profile

Key Roles:

  • Lead for University Research Strategy including trans-disciplinary programmes
  • Lead for University Postgraduate Research Student Programme
  • Lead for Research Excellence Framework Strategy
  • Lead for University Research Quality
  • Lead for Research Ethics and Governance
  • Chair of University Research Advisory Committee
  • Chair of Lancashire Clinical Research Facility Committee
  • Director of Clinical Research Development and Innovation (NHS)
  • Member Clinical Executive Group (NHS)

Research Expertise:

  • Team Building. Professor Jankowski has a strong track record of building large, successful, multi-disciplinary international Research Teams including the Aspirin Esomerazole Chemoprevention Trial (AspECT), the Chemoprevention Of Pre-malignant Intestinal Neoplasia study (ChOPIN) and the EsophaGEal Gene Consortia (EAGLE).
  • Personal Research. His personal Research expertise is in Basic Sciences, Biosciences, Translational Sciences including Genomics Clinical trials, Public Health and Systematic Evidence Based Delphi Reviews.
  • Specific Expertise. Professor Janusz Jankowski leads one of the most successful clinical cancer prevention programmes in the UK on oesophageal cancer.
  • Citations. He has an h-index of 60+ with 15,000+ citations (Google Scholar).


Research Biography

Basic Science: "My group elucidated the site and number of stem cells and their progeny in Barrett’s metaplasia (BM) (Gastroenterology 2013). Furthermore we showed that regulation of stem cell plasticity involves nuclear translocation of -catenin (Am J Pathol 1998 & Gut 2008). Moreover stem cell division may be controlled by mucosal inflammation, especially TNF (Oncogene 2002) and cell adhesion (Lab Invest 1999) (Lab Invest 1998) enabling crypt bifurcation and hence clonal expansion (Gut 2012, Cancer Res 2008 & PNAS 2006)."

Translational and Genomic Science: "We elucidated the epigenetics of the oesophagitis-metaplasia-dysplasia-adenocarcinoma sequence; especially over-expression of the Epidermal Growth Factor Receptor (EGFR) family (Gut 1993) and mutations (Clin Cancer Res 2006). I co-led the application of these findings in large trials addressing EGFR inhibitors in cancer (Lancet Oncology 2014).

My team reported the first Genome Wide Analysis (GWAS) of BM showing predisposition that could perturb inflammatory regulation via obesity (Nature Genet 2012, Gastroenterology 2015 & Lancet 2016). I have contributed to other GWAS; Multiple Sclerosis (Nature 2011), Colitis (Nature Genet 2009), Psoriasis (Nature Genet 2010), Diabetes (Nature Genet 2011), Spondylitis (Nature Genet 2011) and Stroke (NEJM 2012)."

Clinical Trials and Systematic Reviews: "I set up large intervention trials (BMJ 2010) including the longest prospective randomised chemoprevention trial (AspECT) reporting in 2017. This has influenced the aspirin debate urging caution in primary prevention (Lancet Oncol 2009, Lancet 2009 & Lancet 2011).

I led research improving Clinical Standards with formal NHS endorsement on cancer surveillance (Am J Gastroenterology 2007 & Gastroenterology 2004) and endoscopic quality (Gastroenterology 2006; & Am J Gastroenterology 2008). I led the largest English-Language Consensus Reviews, BADCAT (Gastroenterology 2012) and BOBCAT (Am J Gastroenterology 2015) (both NHS badged)."

Janusz co-led an international genetic analysis study into oesophageal cancer, read more now.

Education and Mentoring Expertise:

Professor Jankowski is also committed to education and mentoring clinical scientists in designated roles for the British Society Gastroenterology (BSG) and Royal College Physicians as well as many other Non Government Organisations and NHS trusts.

Past-Chair of BSG Education and Mentoring Committees.

QUALIFICATIONS;

Clinical

M.B. Ch.B., (with Clinical Merits) University of Glasgow, 1983
F.R.C.P.E., Clinical Fellow Royal College of Physicians, Edinburgh, 1999
F.R.C.P., Clinical Fellow Royal College of Physicians, London, 2000
Certificate Specialist Register, GI & Medicine General Medical Council , 2867294, Lond, 1997

Research

M.Sc., cum laude, Clinical Trial Research Linacre College, University of Oxford, 2009
M.D., Molecular Medicine Research University of Dundee, 1995
Ph.D., Translational Pathology Research Imperial College, University of London, 1996

Education

F.A.C.G., Fellow Education American College of Gastroenterology, 2007
A.G.A.F., Fellow Education American Gastroenterology Association, 2012
S.F.H.E.A., Senior Fellow Education Higher Education Academy, Plymouth University, 2014
Certificate of Medical Education Madingley Hall, University of Cambridge, 2013
Train the Trainer (Practical Skills) National NHS Endoscopy Centre, 2013

Leadership and Mentoring

Certificates of Mentoring, (Student & Staff) Gerard Egan & Royal Coll Phys, Leicestershire, 2005
Certificate of Leadership, (Team Building) John Adair, University Hospitals, Warwick, 2014
Certificate of Leadership, (Complex Settings) Leadership Foundation Higher Education, London, 2015

Sports and Sports Medicine

1st Dan Black Belt & Certified Instructor Intern’l TaeKwon-Do Federation, GBR-1-2810, 2015
Certificate of Advanced Life Support Resuscitation Council, UK, 2015
Certificate of Concussion Management American College of Sports Medicine, USA, 2014

Finance

Certificate of Finance for General Managers NHS, UHCW, 2016
Certificate of Finance Management & Growth NHS, 2016

 

Key publications in the last 6 years

1. Gharahkhani P, Fitzgerald RC, Vaughan TL, Palles C, Gockel I, Tomlinson I, Buas MF, May A, Gerges C, Anders M, Becker J, Kreuser N, Noder T, Venerito M, Veits L, Schmidt T, Manner H, Schmidt C, Hess T, Böhmer AC, Izbicki JR, Hölscher AH, Lang H, Lorenz D, Schumacher B, Hackelsberger A, Mayershofer R, Pech O, Vashist Y, Ott K, Vieth M, Weismüller J, Nöthen MM; Barrett's and Esophageal Adenocarcinoma Consortium (BEACON); Esophageal Adenocarcinoma GenEtics Consortium (EAGLE); Wellcome Trust Case Control Consortium 2 (WTCCC2), Attwood S, Barr H, Chegwidden L, de Caestecker J, Harrison R, Love SB, MacDonald D, Moayyedi P, Prenen H, Watson RG, Iyer PG, Anderson LA, Bernstein L, Chow WH, Hardie LJ, Lagergren J, Liu G, Risch HA, Wu AH, Ye W, Bird NC, Shaheen NJ, Gammon MD, Corley DA, Caldas C, Moebus S, Knapp M, Peters WH, Neuhaus H, Rösch T, Ell C, MacGregor S, Pharoah P, Whiteman DC*, Jankowski J*, Schumacher J* (* joint senior authors). Genome-wide association studies in oesophageal adenocarcinoma and Barrett's oesophagus: a large-scale meta-analysis.
Lancet Oncol. 2016 Aug 12. pii: S1470-2045(16)30240-6.

2. Palles C, Chegwidden L, Li X, Findlay JM, Farnham G, Castro Giner F, Peppelenbosch MP, Kovac M, Adams CL, Prenen H, Briggs S, Harrison R, Sanders S, MacDonald D, Haigh C, Tucker A, Love S, Nanji M, deCaestecker J, Ferry D, Rathbone B, Hapeshi J, Barr H, Moayyedi P, Watson P, Zietek B, Maroo N, Gay L, Underwood T, Boulter L, McMurtry H, Monk D, Patel P, Ragunath K, Al Dulaimi D, Murray I, Koss K, Veitch A, Trudgill N, Nwokolo C, Rembacken B, Atherfold P, Green E, Ang Y, Kuipers EJ, Chow W, Paterson S, Kadri S, Beales I, Grimley C, Mullins P, Beckett C, Farrant M, Dixon A, Kelly S, Johnson M, Wajed S, Dhar A, Sawyer E, Roylance R, Onstad L, Gammon MD, Corley DA, Shaheen NJ, Bird NC, Hardie LJ, Reid BJ, Ye W, Liu G, Romero Y, Bernstein L, Wu AH, Casson AG, Fitzgerald R, Whiteman DC, Risch HA, Levine DM, Vaughan TL, Verhaar AP, van den Brande J, Toxopeus EL, Spaander MC, Wijnhoven BP, van der Laan LJ, Krishnadath K, Wijmenga C, Trynka G, McManus R, Reynolds JV, O'Sullivan J, MacMathuna P, McGarrigle SA, Kelleher D, Vermeire S, Cleynen I, Bisschops R, Tomlinson I, Jankowski J. Polymorphisms near TBX5 and GDF7 are associated with increased risk for Barrett's esophagus.
Gastroenterology 2015;148:367-78.

3. Dutton SJ, Ferry DR, Blazeby JM, Abbas H, Dahle-Smith A, Mansoor W, Thompson J, Harrison M, Chatterjee A, Falk S, Garcia-Alonso A, Fyfe DW, Hubner RA, Gamble T, Peachey L, Davoudianfar M, Pearson SR, Julier P, Jankowski J, Kerr R, Petty RD. Gefitinib for oesophageal cancer progressing after chemotherapy (COG): a phase 3, multicentre, double-blind, placebo-controlled randomised trial.
Lancet Oncol 2014;15:894-904.

4. Pan Q, Nicholson AM, Barr H, Harrison LA, Wilson GD, Burkert J, Jeffery R, Alison MR, Looijenga L, Lin WR, McDonald SA, Wright NA, Harrison R, Peppelenbosch MP, Jankowski JA. Identification of Lineage-Uncommitted, Long-Lived, Label-Retaining Cells in Healthy Human Esophagus and Stomach, and in Metaplastic Esophagus.
Gastroenterology 2013;144:761-70.

5. Bennett C, Vakil N, Bergman J, Harrison R, Odze R, Vieth M, Sanders S, Gay L, Pech O, Longcroft-Wheaton G, Romero Y, Inadomi J, Tack J, Corley DA, Manner H, Green S, Al Dulaimi D, Ali H, Allum B, Anderson M, Curtis H, Falk G, Fennerty MB, Fullarton G, Krishnadath K, Meltzer SJ, Armstrong D, Ganz R, Cengia G, Going JJ, Goldblum J, Gordon C, Grabsch H, Haigh C, Hongo M, Johnston D, Forbes-Young R, Kay E, Kaye P, Lerut T, Lovat LB, Lundell L, Mairs P, Shimoda T, Spechler S, Sontag S, Malfertheiner P, Murray I, Nanji M, Poller D, Ragunath K, Regula J, Cestari R, Shepherd N, Singh R, Stein HJ, Talley NJ, Galmiche JP, Tham TC, Watson P, Yerian L, Rugge M, Rice TW, Hart J, Gittens S, Hewin D, Hochberger J, Kahrilas P, Preston S, Sampliner R, Sharma P, Stuart R, Wang K, Waxman I, Abley C, Loft D, Penman I, Shaheen NJ, Chak A, Davies G, Dunn L, Falck-Ytter Y, Decaestecker J, Bhandari P, Ell C, Griffin SM, Attwood S, Barr H, Allen J, Ferguson MK, Moayyedi P, Jankowski JA. Consensus Statements for Management of Barrett's Dysplasia and Early-Stage Esophageal Adenocarcinoma, Based on a Delphi Process (BADCAT).
Gastroenterology 2012;143:336-46

6. Su Z, Gay LJ, Strange A, Palles C, Lescai F, Nanji M, Sasieni P, Howarth K, Trudgill N, Tucker A, Langford C, Edkins S, van de Winkel A, Peppelenbosch MP, van der Laan LJW, Kuipers EJ, Drenth J, Peters W, Reynolds J, Kelleher D, McManus R, Grabsch H, Prenen H, Bisschops R, Krishnadath KK, Siersema P, van Baal J, Middleton M, Gillies R, Petty R, Burch N, Bhandari P, Paterson S, Edwards C, Penman I, Vaidya K, Ang Y, Murray I, Tawil A, Morris D, Nwokolo C, Isaacs P, Rodgers C, Ragunath K, Macdonald C, Haigh C, Monk D, Davies G, Wajed S, Johnston D, , Gibbons M, Cullen S, Church N, Deloukas P, Hunt S, Gray E, Dronov S, Simon Potter, Anderson Mark, Avazeh Tashakkori-Ghanbaria, Blackwell JM, Bramon E, Brown MA, Casas JP, Corvin A, Duncanson A, Markus HS, Mathew CG, McCarthy MI, Palmer CNA, Plomin R, Rautanen A, Sawcer SJ, Trembath RC, Viswanathan AC, Wood NW, Trynka G, Wijmenga C, Cazier JB, Nicholson A, Gellatly NL, Glancy D,, Cooper S, Prew S, Hapeshi J, Ferry D, Rathbone B, Brown Julia, Love S, Brooks C, Attwood S, Watson P, Sanders S, Harrison R, Moayyedi P, deCaestecker J, Barr H, Stupka E, Peltonen L, Spencer CCA, Tomlinson I, Donnelly P, Jankowski JA. Common variants at the MHC locus and at chromosome 16q24.1 predispose to Barrett’s esophagus.
Nature Genet 2012;44:1131-6

7. Nicholson AM, Graham TA, Simpson A, Humphries A, Burch N, Rodriguez-Justo M, Novelli M, Harrison R, Wright NA, McDonald SA, Jankowski JA. Barrett's metaplasia glands are clonal, contain multiple stem cells and share a common squamous progenitor.
Gut 2012;61:1380-9

Google Scholar

Membership of professional and learned bodies

  • British Society of Gastroenterology
  • Royal College of Physicians
  • International Society for Diseases of the Esophagus 

Research Activities

I have extensive research experience from Basic Science (stem cell biology), through to Translational Science (genomics) and then Clinical Studies (Epidemiology, Clinical Trials and Systematic Reviews) 

Projects

  • AspECT chemoprevention Trial 2,513 patients
  • ChOPIN tissue biobank 70,000+ specimens
  • Eagle genomics consortia 10,000+ patients 

Teaching Activities and Responsibilities

  • Medical Students
  • Physician Associates 

External Activities

  • Chair of TransCan2 EU Committee
  • Treasurer International Society for Diseases of the Esophagus 

Conferences

  • Invited Speaker British Society for Gastroenterology
  • Invited Speaker International Society for Diseases of the Esophagus 
  • Invited Speaker International Symposium on Cell/Tissue Injury and Cytoprotection (ISCTICO)
  • Invited Speaker McMaster Invited Review Course in Internal Medicine (MIRCIM)

SOCIAL MEDIA

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