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Gail Welsby

Dr. Gail Welsby

Lecturer in Pharmacology

School of Pharmacy and Biomedical Sciences

Maudland Building, MB107A

+44 (0) 1772 89 3501

gwelsby@uclan.ac.uk

Subject Areas: Biomedical Sciences

Gail joined UCLan in 2011 as an Associate Lecturer in Biochemistry and Pharmacology and took up the position of Lecturer in October 2012. Her research interests include the use of microscopy and flow cytometry to investigate the role of asiatic acid and phytochemicals in the treatment of glioblastoma.

Full Profile

Gail is a Lecturer in Pharmacology at the School of Pharmacy and Biomedical Sciences, University of Central Lancashire. After graduating with an honours degree in Molecular Biology from the University of Glasgow, she went on to obtain an MSc in Forensic Science from the University of Strathclyde. Following a short period working as a trainee Medical Laboratory Scientific Officer, Gail returned to study and gained her PhD characterising the molecular regulation of A3 adenosine receptor internalisation with Dr Tim Palmer at the University of Glasgow. She subsequently took up a postdoctoral position in the US working with Prof. John Lawrence at the University of Virginia, Dept. of Pharmacology. During this time, she investigated the role of phosphorylation on initiation of protein translation via the phosphorylation of PHAS-I (4E-BP1) in response to insulin. Gail returned to Ireland in 2003 to take up the position of Research Team Leader at the Vascular Health Research Centre, DCU, Dublin where she directed and supported projects centred on micro-and macrovascular responses to hypoxia, hyperglycaemia, pulsatile flow and shear stress. Gail moved on to become Laboratory Manager in the Dept. of Molecular Medicine at the Royal College of Surgeons, Ireland where she worked with Dr Stephen Keely on the effects of bile acids on intestinal epithelial cell secretions. Prior to joining UCLan in 2011, Gail spent three years as a Senior Technical officer in the Discipline of Biochemistry, National University of Ireland, Galway. Working with Prof Noel Lowndes as part of the Centre of Chromosome Biology, she investigated the role of various proteins in the repair response of DNA to ionising radiation.

Publications

Walshe, T. E., Connell, P., Cryan, L., Welsby, Gail, O'Brien, C. and Cahill, P. A. (2010) The role of pulsatile flow in controlling microvascular retinal endothelial and pericyte cell apoptosis and proliferation. Cardiovascular Research, 89 (3). pp. 661-670. ISSN 0008-6363

Keating, Niamh, Mroz, Magdalena S., Scharl, Michael M., Marsh, Christine, Welsby, Gail, Hofmann, Alan F. and Keely, Stephen J. (2009) Physiological concentrations of bile acids down-regulate agonist induced secretion in colonic epithelial cells. Journal of Cellular and Molecular Medicine, 13 (8b). pp. 2293-2303. ISSN 15821838

O'Mahony, F., Toumi, F., Mroz, M. S., Welsby, Gail and Keely, S. J. (2008) Induction of Na+/K+/2Cl- cotransporter expression mediates chronic potentiation of intestinal epithelial Cl- secretion by EGF. AJP: Cell Physiology, 294 (6). C1362-C1370. ISSN 0363-6143

Colgan, Olga C., Collins, Nora T., Welsby, Gail, Murphy, Ronan P., Birney, Yvonne A., Cahill, Paul A. and Cummins, Philip M. (2008) Influence of basolateral condition on the regulation of brain microvascular endothelial tight junction properties and barrier function. Brain Research, 1193 (-). pp. 84-92. ISSN 00068993

More publications

Qualifications

PhD Molecular Pharmacology, University of Glasgow, 2001

MSc Forensic Science, University of Strathclyde, 1996

BSc(Hons) Molecular Biology, University of Glasgow, 1995

Memberships

Biochemical Society

External Roles

Brain Tumour North West

Teaching Activities

Gails teaching has focussed mainly in the areas of Biochemistry and Pharmacology. She has taught at both undergraduate and masters levels to students taking courses in Sports Science, Analytical Science, Biomedical Science, Pharmacy and Cancer Biology.

Conferences

British Neuro Oncology Society, Manchester, UK, 2012

Life Sciences, Glasgow, UK 2007

Digestive Disease Week, Washington DC, USA 2007

Irish Society for Gene and Cell Therapy, NUI Galway, Ireland 2007

7th Annual Conference on Arteriosclerosis, Thrombosis, and Vascular Biology, Denver CO, USA 2006

American Heart Association Scientific Sessions 2005, Dallas, TX, USA 2005

6th Annual Conference on Arteriosclerosis, Thrombosis and Vascular Biology, Washington DC, USA 2005

American Heart Association – Scientific Sessions 2004, New Orleans, Louisiana, USA 2004

Glaucoma Society (UK & Eire) 24th Annual Meeting, London, UK 2003

Irish Association of Pharmacologists, Dublin, Ireland 2003

Seventh International Symposium on Adenosine and Adenine Nucleotides, Gold Coast, Australia 2002

The Biochemical Society, Edinburgh, Scotland 2000

Sixth International Symposium on Adenosine and Adenine Nucleotides, Madrid, Spain 2000

Research

The role of dietary supplements as treatments for glioblastoma.
While it is well known that a diet rich in grain, fruit and vegetables can reduce cancer risk, recently there has been an increased interest in the potential chemo-preventive effects of a variety of edible berries. It has been shown in cell lines derived from breast and prostate cancers that juices from berries, including cranberry and pomegranate, can in fact inhibit cancer cell proliferation and increase apoptosis. However, the effects of these compounds on glioma cell lines are less well known. Therefore these studies investigate the effects of pomegranate and cranberry extracts on human glioblastoma cell viability and their potential use as dietary supplemental treatments for glioblastoma.

Nanoparticle design for the treatment of glioblastoma
Due to several complicating factors including susceptibility to brain damage, the inability of many drugs to cross the blood-brain barrier and the limited capacity of the brain to heal itself, conventional therapies to treat glioblastoma are often unsuccessful. Asiatic Acid, a triterpine produced by the plant Centella asiatica, is known to be cytotoxic in many tumour cell lines by inducing apoptosis or cell cycle arrest in a cell-type specific manner. Using a novel polymer, poly-epsilon-caprolactone (PCL), we will develop nanoparticles containing Asiatic Acid that will be analysed for controlled release of Asiatic Acid and its effects on glioma cell viability.

Projects

Characterisation of the effects of edible berry juice on glioma cell viability

Characterisation of the antioxidant capacity of edible berry juices

Designing a drug delivery system for asiatic acid and its effects on glioblastoma cell lines