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Dr. Lorenzo More

Senior Lecturer in Neuroscience

School of Pharmacy and Biomedical Sciences

Maudland Building, MB240

+44 (0) 1772 89 5847

lmore@uclan.ac.uk

Subject Areas: Pharmacy and Pharmacology, Allied Health, Biosciences, Psychology

I work in the field of behavioural genetics and molecular cognition. My research final aim is to understand the cellular and molecular mechanisms underlying learning and memory and thus how the brain stores, retrieves and modifies information.

I exploit environmental enrichment (EE), which is known to enhance cognition in both rodents and humans and to provide the brain with a "cognitive reserve", together with mouse mutants to shed light on the complex molecular machinering involved in environment adaptation and enhanced cognition.

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Lorenzo More undertook a PhD in Neuroscience at the School of Medicine in Padova in 2005 where he studied the effect of urinary pheromones on ovulation and the role of the olfactory systems.

He then moved to Merz Pharmaceuticals in Frankfurt am Main to work on preclinical models of Alzheimer’s, Schizophrenia and Parkinson’s disease.

In 2008 he moved to Nottingham University to investigate the translational properties of associative learning and interval-timing behaviour.

In 2011 he then moved to the San Raffaele Scientific Institute in Milan to study the genetic basis of X-linked Intellectual Disabilities and then in 2014 he moved back to the UK at Warwick University to study the molecular bases of environmental adaptation.

A major development of his recent work on Neuro Developmental Disorders (NDDs), EE, nootropics and neuropeptides concerns the identification of epigenetic markers of psychopathic traits and enhanced cognition.

Qualifications
  • Fellow of the Higher Education Academy, The University of Warwick (UK) 2017
  • Doctor of Research (PhD) in Neuroscience, The University of Padova (Italy) 2005
  • 5-year Laurea (MSc) in Biological Psychology, The University of Padova, 2001

Publications

Daumas S*, Hunter CJ*, Mistry RB*, Morè L*, Privitera L*, Cooper DD, Reyskens KM, Flynn HT, Morris RGM, Arthur JSC, Frenguelli BG (2017). The kinase function of MSK1 regulates BDNF signaling to CREB and basal synaptic transmission, but is not required for hippocampal long-term potentiation or spatial memory. eNeuro: 4(1): ENEURO.0212-16.2017

Morè L, Künnecke B, Yekhlef L, Bruns A, Bianchi V, Taverna S, Marte A, Fedele E, Gatti S, D'Adamo P (2017) Altered Fronto-Striatal Function in the Gdi1-null mouse model of X-linked Intellectual Disability. Neuroscience 344: 346-359

Pennucci R, Talpo F, Astro V, Montinaro V, Morè L, Cursi M, Castoldi V, Chiaretti S, Bianchi V, Marenna S, Cambiaghi M, Leocani L, Biella G, D’Adamo P, de Curtis I (2016) Rac1 and Rac3 GTPases promote the maturation of hippocampal GABAergic interneurons and influence the development of distinct neuronal networks. Cerebral Cortex 26: 873-890

Oettinghaus B, Schulz JM, Restelli LM, Licci M, Savoia C, Schmidt A, Schmitt K, Grimm A, Morè L, Hench J, Tolnay M, Eckert A, D`Adamo P, Franken P, Ishihara N, Mihara K, Bischofberger J, Scorrano L, Frank S (2016) Synaptic dysfunction, memory deficits and hippocampal atrophy due to ablation of mitochondrial fission in adult forebrain neurons. Cell Death and Differentiation 23: 18-28

Research

Molecular Cognition

Projects

  • Epigenetic markers of psychopathic traits and enhanced cognition

Conferences

Hiroshima (Japan), June 2017 International Behavioral Neuroscience Society (IBNS) 26th Annual Meeting - Oral presentation and symposium co-chair: Environmental and pharmacological strategies to enhance cognition

Membership of professional and learned bodies

Publications continued

Daumas S*, Hunter CJ*, Mistry RB*, Morè L*, Privitera L*, Cooper DD, Reyskens KM, Flynn HT, Morris RGM, Arthur JSC, Frenguelli BG (2017). The kinase function of MSK1 regulates BDNF signaling to CREB and basal synaptic transmission, but is not required for hippocampal long-term potentiation or spatial memory. eNeuro: 4(1): ENEURO.0212-16.2017


Morè L, Künnecke B, Yekhlef L, Bruns A, Bianchi V, Taverna S, Marte A, Fedele E, Gatti S, D'Adamo P (2017) Altered Fronto-Striatal Function in the Gdi1-null mouse model of X-linked Intellectual Disability. Neuroscience 344: 346-359


Pennucci R, Talpo F, Astro V, Montinaro V, Morè L, Cursi M, Castoldi V, Chiaretti S, Bianchi V, Marenna S, Cambiaghi M, Leocani L, Biella G, D’Adamo P, de Curtis I (2016) Rac1 and Rac3 GTPases promote the maturation of hippocampal GABAergic interneurons and influence the development of distinct neuronal networks. Cerebral Cortex 26: 873-890


Oettinghaus B, Schulz JM, Restelli LM, Licci M, Savoia C, Schmidt A, Schmitt K, Grimm A, Morè L, Hench J, Tolnay M, Eckert A, D`Adamo P, Franken P, Ishihara N, Mihara K, Bischofberger J, Scorrano L, Frank S (2016) Synaptic dysfunction, memory deficits and hippocampal atrophy due to ablation of mitochondrial fission in adult forebrain neurons. Cell Death and Differentiation 23: 18-28


D’Adamo P, Masetti M, Bianchi V, Morè L, Mignogna ML, Giannandrea M, Gatti S (2014 available online) RAB GTPases and RAB-interacting proteins and their role in the control of cognitive functions. Neuroscience & Biobehavioral Reviews 46: 302-314


Morè L, Jensen G (2014) Acquisition of conditioned responding in a multiple schedule depends on the reinforcement’s temporal contingency with each stimulus. Learning & Memory 21: 258-262


Schlumberger C, Pietraszek M, Gravius A, Klein K-U, Greco S, Morè L, Danysz W (2009) Comparison of positive allosteric modulator of mGlu5 receptor ADX47273 and mGluR2/3 agonist LY354740 in tests for antipsychotic-like activity. European Journal of Pharmacology, Behavioural Pharmacology section, 623: 73-83


Schlumberger C, Schaefer D, Barberi C, Morè L, Nagel J, Pietraszek M, Schmidt WJ, Danysz W (2009) Effects of a metabotropic glutamate receptor group II agonist LY354740 in animal models of positive schizophrenia symptoms and cognition. Behavioural Pharmacology, 20: 56-66


Morè L (2008) Intra-Female Aggression in the Mouse (Mus musculus domesticus) is linked to the Estrous Cycle Regularity but not to Ovulation. Aggressive Behavior, 34: 46-50


Morè L, Gravius A, Nagel J, Valastro B, Greco S, Danysz W (2008) Therapeutically relevant plasma concentrations of memantine produce significant NMDA receptor occupation and do not impair learning in rats. Behavioural Pharmacology, 19: 724-734


Gravius A, Dekundy A, Nagel J, Morè L, Pietraszek M, Danysz W (2008) Investigation on tolerance development to subchronic blockade of mGluR5 in models of learning, anxiety, and levodopa-induced dyskinesia in rats. Journal of Neural Transmission, 115: 1609-1619


Morè L*, Gravius A*, Pietraszek M, Belozertseva I, Malyshkin A, Shekunova E, Barberi C, Schaefer D, Schmidt WJ, Danysz W (2007) Comparison of the mGluR1 antagonist A-841720 in rat models of pain and cognition. Behavioural Pharmacology, 18: 273-281


Morè L (2006) Mouse Major Urinary Proteins Trigger Ovulation via the Vomeronasal Organ. Chemical Senses, 31: 393-401