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Clare Lawrence

Dr. Clare Lawrence

Senior Lecturer in Cell and Molecular Biology

School of Pharmacy and Biomedical Sciences

Maudland Building, MB139

+44 (0) 1772 89 5809

cllawrence@uclan.ac.uk

After graduating with her BSc(Hons) and PhD in Biochemistry from the University of Kent at Canterbury, Clare undertook a number of postdoctoral positions researching the regulation of gene expression using yeast, a simple eukaryotic microorganism. Clare joined UCLan in 2009 where she teaches molecular and cellular biology. Clare has a number of research interests, which use yeast as a paradimic organism for the study of human diseases.

Full Profile

After graduating with her BSc(Hons) in Biochemistry and Biotechnology, Clare undertook a PhD with Prof. Mick Tuite at University of Kent at Canterbury studying prions in yeast. Clare then undertook a postdoctoral position at the University of St. Andrews, researching the response of yeast to citric acid stress, before moving to the Paterson Institute for Cancer Research in Manchester where she worked for five years. During this time Clare worked for Dr Elmar Schiebel, investigating the regulation of the cell cycle in the budding yeast Saccharomyces cerevisiae. This research was published in 2007 in the Journal of Cell Biology. Clare then took a four year postdoctoral position in the lab of Prof. Nic Jones studying the regulation of the stress response in the fission yeast, Schizosaccharomyces pombe. This work produced three publications, two of which were accepted into the Journal of Biological Chemistry and one published in Current Biology.

Clare joined UCLan in 2009 were she teaches molecular and cellular biology. Clare has a range of research interests which utilise yeast , a simple eukaryotic microorganism. There is a high degree of conservation between the cellular processes in yeast and those of human cells. This has meant the successful use of yeast as a paradimic organism for the study of many human diseases, including cancer.

Qualifications
BA (Hons) Business Studies, Open University, 2011
PhD Biochemistry, University of Kent at Canterbury, 2001
BSc (Hons) Biochemistry with Biotechnology, University of Kent at Canterbury, 1998

Publications

Tyler, A.R., Okoh, O.A., Lawrence, C.L., Jones, V.C., Moffatt, C. and Smith, R.B. (2013) N-Alkylated 2,3,3-Trimethylindolenines and 2-Methylbenzothiazoles. Potential Lead Compounds in the Fight against Saccharomyces cerevisiae Infections. European Journal of Medicinal Chemistry. 64, 222-227.

Okoh, O.A., Bisby, R.H., Lawrence, C.L., Rolph, C.E. and Smith, R.B (2013) Promising near-infrared non-targeted probes: benzothiazole heptamethine cyanine dyes. Journal of Sulfur Chemistry, DOI:10.1080/17415993.2013.778258

Lawrence, C.L., Jones, N. and Wilkinson, C.R. (2009) Stress-Induced Phosphorylation of S.pombe Atf1 Abrogates Its Interaction with F Box Protein Fbh1. Curr Biol. 19 (22), 1907-11.

Reiter, W. Watt, D. Dawson, K. Lawrence, C.L. Bahler, J. Jones, N. And Wilkinson, C.R. (2008) Fission yeast MAP kinase Sty1 is recruited to stress-induced genes. J Biol Chem. 283(15), 9945-56.

More publications

Research

Clare’s research interests centre around three main areas :

Using yeast as an in vitro screening tool to identify novel compounds which have potential therapeutic applications. Yeast can be used to evaluate the efficacy of potential compounds for therapeutic use and decipher the functional components of the pathways that regulate the cellular response to these compounds and identify future targets.

Using yeast to investigate the regulation of the stress response by the mitogen activated protein kinase (MAPK) and mTOR signalling pathways. Both of these pathways have been shown to be involved in cell growth, proliferation, motility and survival and have been implicated in the development of cancer. Previous studies have identified a number of downstream targets of stress response pathways being involved in lipid metabolism. Consequently, a better understanding of tumour associated lipid formation may offer targets for the development of new anticancer therapies.

Further research is being undertaken, in collaboration with Dr Lisa Shaw and Dr Jane Alder, to investigate the use of aptamers in tumour targeting and therapy. This research is part of Brain Tumor North West (BTNW), a strategic alliance between UCLan, the University of Wolverhampton and the Lancashire Teaching Hospital's NHS Foundation Trust.

Projects

To investigate the use of novel and established aptamers to determine their use in the diagnosis and treatment of Glioblastoma. Joint project : Clare Lawrence, Jane Alder, Lisa Shaw and Bob Lea

Use of yeast as a model organism to study the role of signalling pathways in the development of cancer.

The role of F-box proteins in regulating the stress response through MAPK and mTOR pathways.

Regulation of Tumour Associated Lipogenesis (joint project with Carole Rolph)

The Development of Fluorescent Dyes and Probes for to Advance Surgical Oncology. Joint project : Robert Smith, Clare Lawrence and Carole Rolph.

Teaching

Course leader for MSc in Pharmaceutical Biotechnology
Module tutor for BL1220 (Integrative Biological Sciences), BL4208 (Biomolecular Technology) and PJ4200 (Cancer Management and Therapy)

Clare is involved in the teaching of molecular and cellular biology on both the biomedical and pharmacy degree programs within the School. She utilises her research interests in gene regulation and cancer biology in a number of modules offered within the school, including Drug Therapies II (BL3212), Biomolecular technology (BL4208) and Cancer management and therapy (PJ4200). Clare also offers project at both undergraduate and postgraduate level which align with her current research interests. She has participated in the UCLan Undergraduate Research Internship Scheme offering research opportunities to students during the summer vacation. In 2011, Clare’s student won best poster for her project.

Memberships

Member of the Biochemical Society

Fellow of the Higher Education Academy

Conferences

Brain Tumor North West 4th Annual Retreat, Preston, UK. Dec 2010, 2011 and 2012.

British Neuro-Oncology Society (BNOS) 2012, Manchester, June 2012.

British Yeast Group Meeting 2009, Cardiff (Presenting Talk Phosphorylation of the S. pombe transcription factor Atf1 abrogates its interaction with the F-box protein Fbh1”) March 2009.

British Yeast Group Meeting 2008, Dublin, Ireland (Presenting Talk “Modulation of S.pombe Atf1 stability via Sty1 mediated phosphorylation”) March 2008.

4th Annual Dundee Upstate/Millipore Cell Signalling Symposium : The Interplay Between Protein Phosphorylation and Ubiquitination in Cell Signalling 2007, Dundee (Presenting Poster "Modulation of S.pombe Atf1 stability via Sty1 mediated phosphorylation") August 2007.

European Fission Yeast Meeting, Cambridge UK (Presenting Talk “Regulation of S.pombe Atf1 protein levels by Sty1-mediated phosphorylation and heterodimerisation with Pcr1) March 2006.

International Yeast Genetics and Molecular Biology Conference, Gotenburg, Sweden (Presenting poster “Evidence for the High Osmolarity Glycerol Mitogen Activated Protein Kinase Pathway (MAPK) regulating adaptation to citric acid stress”) July 2003.