Therapeutic drugs, genes, peptides and other bioactive molecules can be delivered to target cells and organs for the treatments of diseases such as cancers, diabetes and asthma and for responding to specific biological stimuli. Pulmonary delivery of drug, gene and protein in nanocarrier systems is one of our major areas of interest, since the action of drug entrapped in nanocarriers may exhibit prolonged residence time in the lung after inhalation, potentially reducing systemic side effects. Currently, our institute is developing nanocarrier systems for nasal delivery aiming to treat local nasal diseases (e.g. Sinusitis) and systemic diseases (e.g. Diabetes, hormone deficiencies, etc.). Synthesis, properties, computer modelling and applications of a range of functionalised nanocarriers such as dendrimers, liposomes, carbon nanotubes, cochleates, and niosomes are being investigated particularly in the area of aerosol delivery. Moreover, development of methods to manufacturing nanocarriers on a large scale are currently under investigation using vesicular nanosystems by applying various methods of size reduction, freeze-drying and spray-drying.
Recent Conference presentations:
This is a selection of recent publications. Further information about group members publications can be accessed via the staff profiles in the members section, which link to the institutional repository.
Elhissi A, Hidayat K, Phoenix DA, Mwesigwa E, Crean S, Ahmed W, Faheem A, Taylor KM. Air-jet and vibrating-mesh nebulization of niosomes generated using a particulate-based proniosome technology. International Journal of Pharmaceutics, 444, 193-199, 2013.
Staff from across the University form the Institute, bringing together a wealth of experience. Staff with a particular interest in nanotechnologies for drug, gene and protein delivery are:
Nanotechnology for Drug Delivery Mechanism – a project with Sichuan University, China.Liposome Delivery to the Respiratory System
Tat Protein Delivery
Functionalised Carbon Nanotubes For Drug Delivery
Proliposomes for Nasal Delivery
Dendrimers for Drug Delivery