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Biomedical Engineering

The focus of this area is to use engineering principles and technologies to monitor and improve health. Various software and simulations typically used in engineering are being applied to improve surgical procedures in medicine. Materials such as nanostructured coatings (eg diamond) are being investigated for medical applications such as biomedical implants. Nanocarrier system are being engineered by functionalisation to carry therapeutic drugs and delivered to appropriate sites.

Publications and Outputs

2011

M. Mahmoudi, S. Sant, B. Wang, S. Laurent, T. Sen “Superparamagnetic iron oxide nanoparticles (SPIONs): Development, surface modification and applications in chemotherapy” Advanced Drug Delivery Reviews 63, 24, (2011).

F. Casula, A. Corrias, P. Arosio, A. Lascialfari, T. Sen, P. Floris, I. J. Bruce “Design of Water-based Ferrofluids as contrast Agents for Magnetic Resonance Imaging Maria” Journal of Colloid and Interface Science 357, 50 (2011).

D. Rother, T. Sen, D. East, I. J. Bruce “Silicon, silica and its surface patterning with alkoxysilanes for nanomedical applications” Nanomedicine 6, 281 (2011).

Sevink G. J. A., Pinna M., Langner K. M., Zvelindovsky A. V., “Selective disordering of lamella-forming diblock copolymers under an electric field”, Soft Matter 7 (2011) 5161-5170.

Denham N., Holmes M.C., Zvelindovsky A.V., “The Phases in a Non-Ionic Surfactant (C12E6) – Water Ternary System: A Coarse-Grained Computer Simulation”, J. Phys. Chem. B 115 (2011) 1385–1393.

Harris, F., Dennison, S.R. and Phoenix 2011 On the selectivity and efficacy of defence peptides with respect to cancer cells. Medicinal Research Reviews

Dennison, S.R. and Phoenix, D.A. 2011. Influence of C-terminal amidation on efficacy of modelin-5. Biochemistry. 50(9) 1514-1523

Harris, F, Dennison, S.R. and Phoenix, D.A. 2011. Anionic antimicrobial peptides from eukaryotic organisms and their mechanisms of action. Current Chemical Biology. 5(2) 142-153

 

2010

Pinna M., Hiltl S., Guo X., Böker A., Zvelindovsky A. V., “Block Copolymer Nanocontainers”, ACS Nano 5 (2010) 2845

Dennison, SR. Harris, F. Bhatt, T. Singh, J and Phoenix, D.A., “A theoretical analysis of secondary structural characteristics of anticancer peptides“, Molecular and cellular biochemistry. 333(1-2) (2010) 129

Hollingbery L. and Hull T. R., “A Review of The Structure and Thermal Decomposition of Hydromagnesite and Huntite”, Thermochimica Acta (2010), doi:10.1016/j.tca.2010.06.012

Sacristán M., Hull T. R., Stec A. A., Ronda J. C., , Galià M, Cádiz M. V., “Cone Calorimetry Studies of Fire Retardant Soybean-Oil-Based Copolymers Containing Silicon or Boron: comparison of additive and reactive approaches”, Polymer Degradation and Stability. 95 (2010) 1269

Patel P, Hull TR, McCabe RW, Flath D, Grasmeder J, Percy M, “Mechanism of thermal decomposition of poly(etheretherketone) (PEEK) from a review of decomposition studies”, Polymer Degradation and Stability 95 (2010) 709

Stec A. A. and Jennifer Rhodes J., “Smoke and Hydrocarbon Yields from Fire Retarded Polymer Nanocomposites”, Polymer Degradation and Stability, (in press) March (2010) doi:10.1016/j.polymdegradstab.2010.03.032

Rhodes J, Smith C. and Stec A. A., Characterisation of soot particulates from fire retarded and nanocomposite materials, and their toxicological impact. Polymer Degradation and Stability, (in press) March (2010) doi:10.1016/j. polymdegradstab.2010.07.002

Sen T., Bruce I.J., Mercer T. “Fabrication of novel hierarchically ordered porous magnetic nanocomposites for bio-catalysis” Chem. Commun. 46 (2010) 6807.

Mahmoudi M., Sant S., Wang B., Laurent S. , Sen T., “Superparamagnetic iron oxide nanoparticles (SPIONs): Development, surface modification and applications in chemotherapy” Adv. Drug. Deliv. Rev., (2010) doi:10.1016/j. addr.2010.05.006

Itoh, K., Hatakeyama, T., Kimura, Y., Shimoyama, T., Miyazaki, S., D’Emanuele, A., Attwood, D. “Effect of D-sorbitol on the thermal gelation of methylcellulose formulations for drug delivery” Chem. Pharm. Bull., 58 (2010) 247.

Itoh, K., Tsuruya, R., Hatakeyama, T., Shimoyama, T., Watanabe, H., Miyazaki, S., D’Emanuele, A., Attwood, D. “In situ gelling xyloglucan/alginate liquid formulation for oral sustained drug delivery to dysphagic patients”. Drug Dev. Ind. Pharm., 36 (2010) 449

Elhissi, A.M.A., Ashraful Islam, Md, Arafat, B., Taylor, M., Ahmed, W., “Development and characterization of freeze-dried antiasthma liposomes”. Micro & Nano Letters, 5 (2010) 184.

Said R., Ghumman C. A. A., Teodoro O. M. N. D., Ahmed W., Abuazza A., and Gracio J., “Effects of Bias Voltage on Diamond Like Carbon Coatings Deposited Using Titanium Isopropoxide (TIPOT) and Acetylene/Argon Mixtures onto Various Substrate Materials”, J. Nanosci. Nanotechnol. 10 (2010) 2552

Elhissi, A.M.A., Gill, H., Ahmed, W., Taylor, K.M.G., “Vibrating-mesh nebulization of liposomes using an ethanol-based proliposome technology”, Accepted J Liposome Research (2010)

Said R., Ahmed W., and Gracio J., “Closed Field Unbalanced Magnetron Sputtering Ion Plating of Ni/Al Thin Films: Influence of the Magnetron Power”, J. Nanosci. Nanotechnol. 10 (2010) 2558

Said R. , Ahmed W., Abuain T., Abuazza A., and Gracio J., “Growth and Characterisation of NiAl and N-Doped NiAl Films Deposited by Closed Field Unbalanced Magnetron Sputtering Ion Plating Using Elemental Ni and Al Targets”, J. Nanosci. Nanotechnol. 10 (2010) 2600

Whitty J.P.M., Henderson B., Francis J. and Lloyd N., “Optimized aspect ratios of restrained thick-wall cylinders by virtue of Poisson’s ratio selection (Part One- Pressure application)”, J. Nuc. Eng. Des., (2010).

van de Waterbeemd M. , Sen T., Biagini S. and Bruce I. J., “Surface functionalisation of magnetic nanoparticles: Quantification of surface to bulk amine density” Micro & Nano Letters 5 (2010) 282

Sen T. “Novel Nanocomposites: Hierarchically Ordered Porous Silica for the Immobilisation of Enzyme as Bio-catalyst” NSTI-Nanotech 2010, www.nsti.org., ISBN 978-1-4398-3401-5 ,1 (2010) 784, CRC press, Taylor & Francis group.

Sen T., Sheppard S., Mercer T., Elhissi A., “Magnetoliposomes: Stability of magnetic nanoparticles in suspension for drug delivery”NSTI-Nanotech 2010, www.nsti.org., ISBN 978-1-4398-3401-5, 1 (2010) 924, CRC press, Taylor & Francis group.

Sen T. and Bruce I. J., “A generalized approach for the surface engineering of nanoparticles in suspension for highly efficient hybrid capture of bio-molecules” NSTI-Nanotech 2010, www.nsti.org., ISBN 978-1-4398-3401-5,.1 (2010) 596, CRC press, Taylor & Francis group.

 

2009

Pinna M., Schreier L., Zvelindovsky A. V. “Mechanisms of electric-field-induced alignment of block copolymer lamellae”, Soft Matter 5 (2009) 970

Guo X., Pinna M., Zvelindovsky A. V. “Parallel algorithm for Cell Dynamics Simulation of Soft Nano-Structures Matter” Parallel scientific computing and optimization: Advances and Application 27 253-262. Book Series: Springer series in Optimization and its Applications, (2009).

Dennison, S.R., Morton, L.H.G, Shorrocks, A.J, Harris, F. & Phoenix, D.A., “A study on the interactions of Aurein 2.5 with bacterial membranes”, Colloids and Surfaces B: Biointerfaces, 68(2) (2009) 225

Dennison, S.R., Harris, F & Phoenix, D.A. “A Study on the Importance of Pheny-laniline for Aurein functionality”. Protein and Peptide Letters 16(12) (2009) 1455

Dennison, SR. Harris, F. Bhatt, T. Singh, J and Phoenix, D.A., ”The effect of C-terminal amidation on the efficacy and selectivity of antimicrobial and anticancer peptides”, Molecular and cellular biochemistry 332(1-2) (2009) 43

Harris, F, Dennison, SR and Phoenix D.A., “Anionic antimicrobial peptides from eukaryotic organisms”, Current Protein and Peptide Science. 10(6) (2009) 585

Wang D. Y., Wang J. S., Ge X. G., Wang Y. Z., Stec A. A. and Hull T. R., “Preparation and characterisation of a novel flame retarded PET/? zirconium phosphate nanocomposite (?-ZrP)”, Polymer Degradation and Stability 94 (2009) 544

Members

Institute Staff

Staff from across the University form the Institute bringing a wealth of experience together. Staff with a particular interest in Nanobiomaterials and Nanostructures are:

Professor D A Phoenix

Professor M Holmes

Dr S Dennison

Related Projects

Biological and Biochemical Models of Nanoparticulate Toxicity

Engineering Surfaces with Diamond for Dental Tools

Computational Blood Flow Modelling Through Sutured and Coupled Microvascular Anastomoses

Dynamic Modelling of Cellular Solids for Trabecular Bone Replacement

Analysis and prediction of peptides and proteins propensity for amyloidogenicity